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Two Types of Voltage-dependent Outward Potassium Currents in Smooth Muscle Cells of Rabbit Basilar Atery

Kang, Tong-Mook   (Samsung Biomedical Research InstituteCC0102064  ); So, In-Suk   (Department of Physiology and Biophysics, Seoul National University College of MedicineUU0000691  ); Uhm, Dae-Yong   (Department of Physiology, College of Medicine, Sung Kyun Kwan UniversityUU0000759  ); Kim, Ki-Whan   (Department of Physiology and Biophysics, Seoul National University College of MedicineUU0000691  );
  • 초록

    We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current ( $I_{K(V)}$ ) and 'A-like' transient outward K current ( $I_{to}$ ) with patch-clamp technique in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power ( $n^2$ ) in $I_{K(V)}$ and fourth power ( $n^4$ ) in $I_{to}$ . The activation, inactivation and recovery time courses of $I_{to}$ were much faster than that of $I_{K(V)}$ . The steady-state activation and inactivation of $I_{K(V)}$ was at the more hyperpolarized range than that of $I_{to}$ contrary to the reports in other vascular SMCs. Tetraethylammonium chloride (TEA; 10 mM) markedly inhibited $I_{K(V)}$ but little affected $I_{to}$ . 4-Aminopyridine (4-AP) had similar inhibitory potency on both currents. While a low concentration of $Cd^{2+}$ (0.5 mM) shifted the current- voltage relationship of $I_{to}$ to the positive direction without change of maximum conductance, $Cd^{2+}$ did not cause any appreciable change for $I_{K(V)}$ .


  • 주제어

    Basilar artery .   Delayed rectifier K current .   Transient outward K current .   4-AP .   TEA.  

 저자의 다른 논문

  • So, In-Suk (30)

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    2. 1987 "기니피그 위 평활근의 기계적 및 전기적 활동에 대한 아데노신 효과" 대한생리학회지 = Korean journal of physiology 21 (2): 225~239    
    3. 1992 "Ionic Dependence and Modulatory Factors of the Background Current Activated by Isoprenaline in Rabbit Ventricular Cells" 대한생리학회지 = Korean journal of physiology 26 (1): 15~25    
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    5. 1992 "Calcium Current and Background Current Activation in L-triiodothyronine Loaded Ventricular Myocytes of the Rabbit" 대한생리학회지 = Korean journal of physiology 26 (2): 99~111    
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    7. 1993 "Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach" 대한생리학회지 = Korean journal of physiology 27 (2): 115~122    
    8. 1993 "Effect of Dopamine on the $Ca^{2+}\;-dependent\;K^+\;currents$ in Isolated Single Gastric Myocytes of the Guinea-pig" 대한생리학회지 = Korean journal of physiology 27 (2): 139~150    
    9. 1995 "Contractile and Electrical Responses of Guinea-pig Gastric Smooth Muscle to Bradykinin" 대한생리학회지 = Korean journal of physiology 29 (2): 233~241    
    10. 1997 "Effects of Arachidonic Acid on the Calcium Channel Current $(I_{Ba})$ and on the Osmotic Stretch-induced Increase of $I_{Ba}$ in Guinea-Pig Gastric Myocytes" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (4): 435~443    
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