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Cloning of Mouse AQP-CD Gene

Jung, Jin-Sup   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Kim, Joo-In   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Oh, Sae-Ok   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Park, Mi-Young   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Bae, Hae-Rhan   (Department of Physiology, College of Medicine, Dong-A UniversityUU0000480  ); Lee, Sang-Ho   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  );
  • 초록

    Water transport in highly-permeable membranes is facilitated by some specialized pathways, which are called aquaporins (AQP). AQP1 (AQP-CHIP) is the first recognized aquaporin identified from red cells and renal proximal tubules. Up until now 4 other aquaporin homologs have been reported. Each aquaporin has its unique tissue distribution and regulatory mechanims. To elucidate molecular mechanisms for their transcription regulation and tissue-specific expression isolation of aquaporin genes is required. To clone promoters of the AQP family mouse genomic library was screened by the 1st exon-specific probe of AQP4, and 5 different plaques were positively hybridized. Phage DNAs were purified and characterized by restriction mapping and sequencing. One of them is the mouse AQP-CD gene. The gene was consisted of 4 exons and the exon-intron boundaries of mouse AQP-CD gene were identified at identical positions in other related genes. The 5'-flanking region of AQP-CD gene contains one classic TATA box, a GATA consensus sequence, an E-box and a cyclic AMP-responsive element. The cloning of the mouse AQP-CD gene, of which product is expressed in the collecting duct and is responsible for antidiuresis by vasopressin, will contribute to understand the molecular mechanisms of tissue-specific expression and regulation of AQP-CD gene under various conditions.


  • 주제어

    Aquaporin-CD .   Gene .   Cloning.  

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  • 정진섭 (27)

    1. 1990 "토끼 기관평활근 수축에서 G Protein의 역할" 대한생리학회지 = Korean journal of physiology 24 (2): 353~362    
    2. 1991 "Effect of Probenecid on Urate Excretion in the Cat Kidney" 대한생리학회지 = Korean journal of physiology 25 (1): 37~48    
    3. 1991 "Proton Transport in Human Placental Microvillous Membrane Vesicles" 대한생리학회지 = Korean journal of physiology 25 (1): 49~60    
    4. 1991 "Effect of Renal Ischemia in Tetraethylammonium Transport in Rabbit Renal Coritcal Slices" 대한생리학회지 = Korean journal of physiology 25 (2): 171~177    
    5. 1991 "Inhibition of Dicarboxylate Transport by p-chloromercuribenzoic Acid (PCMB) in Plasma Membrane Vesicles of Rabbit Proximal Tubule" 대한생리학회지 = Korean journal of physiology 25 (2): 179~188    
    6. 1995 "Effect of Cyclic Nucleotides on Phorbol Ester-Induced Contraction in Rabbit Carotid Artery" 대한생리학회지 = Korean journal of physiology 29 (1): 39~50    
    7. 1996 "Transepithelial Transport of Organic Cation and Its Inhibition by Sulfhydryl and Carboxyl Reagents in Opossum Kidney Cell Monolayer" 대한생리학회지 = Korean journal of physiology 30 (1): 53~62    
    8. 1997 "Functional Characteristics of Neutral Amino Acid Transporter in Opossum Kidney (OK) Cells" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (2): 185~193    
    9. 1997 "Regulation of AQP-4 Water Channel Expression in the Brain during Development and by Ischemia" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (5): 495~504    
    10. 1998 "cAMP-Dependent Signalling is Involved in Adenosine-Stimulated $Cl^-$ Secretion in Rabbit Colon Mucosa" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (4): 521~527    
  • Oh, Sae-Ok (5)

  • Park, Mi-Young (1)

  • 배혜란 (10)

  • 이상호 (17)

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