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Distributional Patterns of Phospholipase C Isozymes in Heart and Brain of Spontaneously Hypertensive and Normotensive Rats

Choi, Ji-Woong   (Department of Pharmacology, Catholic University Medical CollegeUU0013933  ); Cho, Young-Jin   (Department of Pharmacology, Catholic University Medical CollegeUU0013933  ); Cha, Seok-Ho   (Department of Pharmacology, Catholic University Medical CollegeUU0013933  ); Lee, Kweon-Haeng   (Department of Pharmacology, Catholic University Medical CollegeUU0013933  ); Lee, Sang-Bok   (Department of Pharmacology, Catholic University Medical CollegeUU0013933  );
  • 초록

    The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in the genetic hypertensive rats. As the first step of knowing the role of PLC on hypertension, we investigated the distribution of 6 PLC isozymes $(PLC-{\beta}1,\;-{\beta}3,\;-{\beta}4,\;-{\gamma}1,\;-{\gamma}2\;and\;-{\delta}1)$ in the heart and brain, which are concerned with hypertension, in the normotensive Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR) using the western blotting and immunocytochemistry. The immunoreactivities of PLC isozymes in brain were detected, but there were no distributional and quantitative differences between the WKY and SHR. In the heart, but the immunoreactivities to $PLC-{\beta}1$ and $-{\gamma}2$ in the SHR were higher than those in WKY. In immunocytochemistry to confirm these western blotting data, $PLC-{\beta}1$ and $-{\gamma}2$ were localized in cardiac myocytes and the intensities of immunoreactivity in SHR were stronger than that in WKY. These results suggest that $PLC-{\beta}1$ and $-{\gamma}2$ would have possibility to concern with the establishment of spontaneous hypertension.


  • 주제어

    PLC isozymes .   Western blot .   Immunocytochemistry .   Heart .   Brain .   SHR.  

 저자의 다른 논문

  • Cho, Young-Jin (5)

    1. 1995 "Effect of Biphenyl Dimethyl Dicarboxylate on Chemical-Induced Hepatotoxicity" 한국독성학회지 = The Korean journal of toxicology 11 (2): 181~185    
    2. 1997 "Endothelin Increases Intracellular Free Calcium in Isolated Rat Nephron" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (5): 565~572    
    3. 1998 "Hydroxyl Radical-Mediated Commitment of HL-60 Cells to Differentiation: Modulation of Differentiation Process by Phosphodiesterase Inhibitors" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (3): 369~376    
    4. 2005 "5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 9 (5): 255~262    
    5. 2006 "Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 10 (1): 31~38    
  • Cha, Seok-Ho (2)

  • Lee, Kweon-Haeng (8)

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