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Changes in Renal Brush-Border Sodium-Dependent Transport Systems in Gentamicin-Treated Rats

Suhl, Soong-Yong   (Department of Physiology, Kosin Medical College  ); Ahn, Do-Whan   (Department of Physiology, Kosin Medical College  ); Kim, Kyoung-Ryong   (Department of Physiology, Kosin Medical College  ); Kim, Jee-Yeun   (Department of Physiology, Kosin Medical College  ); Park, Yang-Saeng   (Department of Physiology, Kosin Medical College  );
  • 초록

    To elucidate the mechanism of gentamicin induced renal dysfunction, renal functions and activities of various proximal tubular transport systems were studied in gentamicin-treated rats (Fisher 344). Gentamicin nephrotoxicity was induced by injecting gentamicin sulfate subcutaneously at a dose of 100 $mg/kg{\cdot}day$ for 7 days. The gentamicin injection resulted in a marked polyuria, hyposthenuria, proteinuria, glycosuria, aminoaciduria, phosphaturia, natriuresis, and kaliuresis, characteristics of aminoglycoside nephropathy. Such renal functional changes occurred in the face of reduced GFR, thus tubular transport functions appeared to be impaired. The polyuria and hyposthenuria were partly associated with a mild osmotic diuresis, but mostly attributed to a reduction in free water reabsorption. In renal cortical brush-border membrane vesicles isolated from gentamicin-treated rats, the $Na^+$ gradient dependent transport of glucose, alanine, phosphate and succinate was significantly attenuated with no changes in $Na^+-independent$ transport and the membrane permeability to $Na^+$ . These results indicate that gentamicin treatment induces a defect in free water reabsorption in the distal nephron and impairs various $Na^+-cotransport$ systems in the proximal tubular brush-border membranes, leading to polyuria, hyposthenuria, and increased urinary excretion of $Na^+$ and other solutes.


  • 주제어

    Gentamicin .   Renal function .   Renal brush-border membrane .   Glucose .   Amino acid .   Phosphate .   Succinate.  

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