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Differential Inhibitory Action of Taurine between Electrically Evoked Response and Low $Mg^{++}-Induced$ Spontaneous Activity in the CA1 Area of the Rat Hippocampal Slices

Baek, Soo-Youn   (Department of Biology, College of Natural Science, Inha UniversityUU0001092  ); Yang, Sung-Gu   (Department of Biology, College of Natural Science, Inha UniversityUU0001092  ); Lee, Chang-Joong   (Department of Biology, College of Natural Science, Inha UniversityUU0001092  );
  • 초록

    Although one of the major physiological functions of taurine(2-aminoethanesulfonic acid) is the inhibitory action on the central nervous system(CNS), the mechanism of taurine in controlling the neuronal excitation in the CNS has been in controversy. Electrically evoked pEPSP and spontaneous activity induced by the perfusion of low $Mg^{++}-ACSF$ were recorded in the CA1 pyramidal cell layer of the hippocampal slice. To test the inhibitory effect of taurine on spontaneous responses, taurine was treated for 2 min at various concentrations(1 mM-10 mM). Taurine reduced the spontaneous activity by 22.2% at 1 mM, and 100% at 2 mM in low $Mg^{++}-ACSF$ . Evoked response was induced by electrical stimulation of Schaffer collateral-commissural fibers. Taurine reduced the evoked response by 11.68% at 3 mM, and 24.25% at 5 mM. Even 20 mM of taurine reduced the evoked response only by 24 % after 5 min treatment. That is, the inhibitory efficacy was much higher in spontaneous activity than in evoked response. The $GABA_A$ receptor antagonist, 100 uM bicuculline, blocked the inhibitory action of taurine, while $GABA_B$ receptor antagonist, 700 uM phaclofen, did not. Taurine blocked the spontaneous activity in the presence of CNQX, and did not block the electrically evoked responce in the presence of APV. The results suggest that taurine causes hyperpolarization in the cell by binding to $GABA_A$ receptor and preferentially attenuates NMDA receptor-mediated hyperexcitation, leaving synaptic transmission unmodified.


  • 주제어

    Taurine .   Hippocampus .   CA1 .   GABA .   NMDA.  

 저자의 다른 논문

  • Lee, Chang-Joong (7)

    1. 1997 "Effects of Taurine on Glutamate-induced Neurotoxicity and Interleukin-6 mRNA Expression in Astrocytes" Korean journal of biological sciences 1 (3): 467~473    
    2. 2000 "Ginsenoside Rb$_1$ Reduces Spontaneous Bursting Activity in Thalamocortical Slices of the Rat" Journal of ginseng research = 高麗人參學會誌 24 (3): 134~137    
    3. 2003 "Alcohol Impairs learning of T-maze Task but Not Active Avoidance Task in Zebrafish" Korean journal of biological sciences 7 (4): 303~307    
    4. 2009 "Ginsenoside Rg1 Reduced Spontaneous Epileptiform Discharges and Behavioral Seizure in the Zebrafish" Journal of ginseng research = 高麗人參學會誌 33 (1): 48~54    
    5. 2011 "MK-801-induced learning impairments reversed by physostigmine and nicotine in zebrafish" Animal cells and systems 15 (2): 115~121    
    6. 2012 "Anxiolytic effects of an acetylcholinesterase inhibitor, physostigmine, in the adult zebrafish" Animal cells and systems 16 (3): 198~206    
    7. 2014 "Valproic acid decreases cell proliferation and migration in the cerebellum of zebrafish larvae" Animal cells and systems 18 (2): 101~108    

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