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Effect of pH on the ATP-sensitive $K^+$ Channel in Aortic Smooth Muscle Cells from Rats

Kim, Se-Hoon   (Department of Physiology, College of Medicine, Chungnam National UniversityUU0001302  ); Kim, Il-Su   (Department of Physiology, College of Medicine, Chungnam National UniversityUU0001302  ); Kim, Hoe-Suk   (Department of Physiology, College of Medicine, Chungnam National UniversityUU0001302  ); Jeon, Byeong-Hwa   (Department of Physiology, College of Medicine, Chungnam National UniversityUU0001302  ); Chang, Seok-Jong   (Department of Physiology, College of Medicine, Chungnam National UniversityUU0001302  );
  • 초록

    The effects of pH on $K^+$ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell $K^+$ currents were recorded in the conventional configuration of the voltage-clamp technique. Pinacidil (10uM) activated the whole-cell current and the pinacidil-activated current was completely inhibited by glibenclamide (10uM) , an inhibitor of ATP-sensitive $K^+$ channel ( $K_{ATP}$ channel). Pinacidil-activated current was reversed at near the $K^+$ equilibrium potential. This current was time- and voltage-independent and reduced by elevating intracellular ATP. Pinacidil-activated current was reduced by lowering the external pH. However, alteration of internal pH has controversial effects on pinacidil-activated current. When the single cell was dialyzed with 0.1 mM ATP, alteration of internal pH had no effect on pinacidil-activated $K^+$ current. In the contrast, when the single cell was dialyzed with 3 mM ATP, pinacidil-activated current was increased by lowering internal pH. Our results suggest that $K^+$ channel activated by pinacidil may be $K_{ATP}$ channel and internal $H^+$ may reduce the inhibitory effect of ATP on $K_{ATP}$ channel.


  • 주제어

    pH .   $K^+-channel$ .   Vascular smooth muscle .   Pinacidil .   Glibenclamide.  

 저자의 다른 논문

  • Kim, Hoe-Suk (10)

    1. 1994 "Ca-dependent Alteration in Basal Tone, Basal $^{45}Ca$ Uptake and $^3H-nitrendipine$ Binding in the Aorta of Spontaneously Hypertensive Rats" 대한생리학회지 = Korean journal of physiology 28 (1): 27~35    
    2. 1994 "Effect of pH on the Vascular Tone and $^{45}Ca$ Uptake in the Aorta of Spontaneously Hypertensive Rats" 대한생리학회지 = Korean journal of physiology 28 (2): 169~179    
    3. 1994 "Effects of cGMP on the Contractility and Ca Movement in the Aorta of Normotensive Wistar-Kyoto Rats and Spontaneously Hypertensive Rats" 대한생리학회지 = Korean journal of physiology 28 (2): 181~190    
    4. 1996 "Enhanced Vasorelaxation Response to Cromakalim in Spontaneously Hypertensive Rats" 대한생리학회지 = Korean journal of physiology 30 (1): 11~20    
    5. 1996 "Effect of Blood Pressure on the Endothelium-Dependent Contraction in Rat Aorta" 대한생리학회지 = Korean journal of physiology 30 (1): 21~31    
    6. 1996 "Endothelium-dependent Contraction of Aorta in One-kidney, One-clip Goldblatt Hypertensive Rat" 대한생리학회지 = Korean journal of physiology 30 (2): 269~278    
    7. 1999 "Mechanism of Membrane Hyperpolarization by Extracellular $K^+$ in Resistance-sized Cerebral Arterial Muscle Cell of Rabbit" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (1): 1~10    
    8. 1999 "Decreased Voltage Dependent $K^+$ Currents in Cerebral Arterial Smooth Muscle Cells of One-Kidney, One-Clip Goldblatt Hypertensive Rat" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (5): 471~479    
    9. 1999 "신성고혈압백서에서 혈압에 미치는 고려홍삼사포닌과 비사포닌의 효과" Journal of ginseng research = 高麗人參學會誌 23 (2): 81~87    
    10. 2000 "Alteration of 4-Aminopyridine-Sensitive, Voltage-Dependent $K^+-Channel$ in Arterial Smooth Muscle Cells of One-Kidney, One-Clip Goldblatt Hypertensive Rats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 4 (5): 385~391    
  • Jeon, Byeong-Hwa (27)

  • 장석종 (19)

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