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Cytochrome P450 2E1 Activity in a Korean Population

Muhn, Dou-Hyun   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Chae, Ji-Min   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Bahn, Jae-Yong   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Song, Hae-Jung   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Kim, Hyung-Kee   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Kwon, Jun-Tack   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  ); Sohn, Dong-Ryul   (Department of Clinical Pharmacology, Soonchunhyang University College of MedicineUU0000848  );
  • 초록

    Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible interindividual and interethnic variation. However, no pharmacogenetic information on CYP2E1 polymorphism has been available from a Korean population. The aim of this study was to explore the pharmacogenetics of CYP2E1 polymorphism in a native Koreans after an oral 400 mg dose of chlorzoxazone administered to 128 subjects. Urine samples were collected during the subsequent 8-hour period and urinary concentrations of chlorzoxazone and 6-hydroxychlorzoxazone were determined by a high performance liquid chromatography with an ultraviolet detector. The limit of detection in the samples was found to be $0.5\;{\mu}g/ml$ . The mean value of the 6-hydroxychlorzoxazone excreted in 8 hr urine expressed as the percentage was 48.2 13.8%. The frequency distribution of percentage of the administered dose excreted as the 6-hydroxy metabolite was unimodally distributed in the subjects studied. However, the values showed wide (7-fold) interindividual difference, ranged from 11.6% to 79.8% of the dose of chlorzoxazone. Thus, it was considered that the pharmacogenetic characteristics of CYP2E1 in a Korean population did not represent multimodal distribution in the 6-hydroxychlorzoxazone excreted in 8-hr urine expressed as the percentage. And the activity of the CYP2E1 in a Korean population seemed to be less compared with that of the Caucasian subjects.


  • 주제어

    Cytochrome P450 2E1 .   Chlorzoxazone .   Koreans.  

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