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흰쥐의 운동유발전위에 대한 전정신경핵과 연수망상핵의 역할
Role of the Vestibular and Medullary Reticular Neuclei for the Motor Evoked Potentials in Rats

이문영   (원광대학교 의과대학 생리학교실UU0001021  ); 이성호   (원광대학교 의과대학 생리학교실UU0001021  ); 김재효   (원광대학교 의과대학 생리학교실UU0001021  ); 박병림   (원광대학교 의과대학 생리학교실UU0001021  ); 김민선   (원광대학교 의과대학 생리학교실UU0001021  );
  • 초록

    The motor evoked potentials (MEPs) have been advocated as a method of monitoring the integrity of spinal efferent pathways in various injury models of the central nervous system. However, there were many disputes about origin sites of MEPs generated by transcranial electrical stimulation. The purpose of present study was to investigate the effect of major extrapyramidal motor nuclei such as lateral vestibular nucleus (VN) and medullary reticular nucleus (mRTN) on any components of the MEPs in adult Sprague-Dalwey rats. MEPs were evoked by electrical stimulation of the right sensorimotor cortex through a stainless steel screw with 0.5mm in diameter, and recorded epidurally at T9 - T10 spinal cord levels by using a pair of teflon-coated stainless steel wire electrodes with 1mm exposed tip. In order to inject lidocaine and make a lesion, insulated long dental needle with noninsulated tips were placed stareotoxically in VN and mRTN. Lidocaine of $2{\sim}3\;{\mu}l$ was injected into either VN or mRTN. The normal MEPs were composed of typical four reproducible waves; P1, P2, P3, P4. The first wave (P1) was shown at a mean latency of 1.2 ms, corresponding to a conduction velocity of 67.5 m/sec. The latencies of MEPs were shortened and the amplitudes were increased as stimulus intensity was increased. The amplitudes of P1 and P2 were more decreased among 4 waves of MEPs after lidocaine microinjection into mRTN. Especially, the amplitude of P1 was decreased by 50% after lidocaine microinjection into bilateral mRTN. On the other hand, lidocaine microinjection into VN reduced the amplitudes of P3 and P4 than other MEP waves. However, the latencies of MEPs were not changed by lidocaine microinjection into either VN or mRTN. These results suggest that the vestibular and reticular nuclei contribute to partially different role in generation of MEPs elicited by transcranial electrical stimulation.


  • 주제어

    Motor evoked potentials .   Sensorimotor cortex .   Vestibular nucleus .   Medullary reticular nucleus .   Lidocaine.  

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    3. 1997 "Correlation Between Electrical Activity of Type I Neuron and c-Fos Expression in the Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (5): 505~513    
    4. 1999 "Temporal Changes in Neuronal Activity of the Bilateral Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (5): 481~490    
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  • 이성호 (3)

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