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신생흰쥐 척수후근신경절 세포에서 전압의존성 $K^+$ 전류의 동정
Characterization of Voltage-Gated Potassium Currents in Dorsal Root Ganglion Neurons of Neonatal Rats

김지목   (서울대학교 의과대학 생리학교실UU0000691  ); 정승준   (서울대학교 의과대학 생리학교실UU0000691  ); 김상정   (서울대학교 의과대학 생리학교실UU0000691  ); 김전   (서울대학교 의과대학 생리학교실UU0000691  );
  • 초록

    Dorsal root ganglion (DRG) is composed of neuronal cell bodies of primary afferents with diverse functions. Various types of ion channels present on DRG neurons may reflect those functions. In the present study, voltage-gated potassium currents in DRG neurons of neonatal rats were characterized by whole-cell voltage clamp method. Two types of delayed rectifier and three types of transient potassium currents were identified according to their electrophysiological properties. The delayed rectifier currents were named $I_{Ke}$ (early inactivating) and $I_{K1}$ (late inactivating). Steady state inactivation of $I_{Ke}$ began from -100 mV lasting until -20 mV. $I_{K1}$ could be distinguished from $I_{Ke}$ by its inactivation voltage range, from -70 mV to +10 mV. Three transient currents were named $I_{Af}$ (fast inactivation), $I_{Ai}$ (intermediate inactivation kinetics), and $I_{As}$ (slow inactivation). $I_{Af}$ showed fast inactivation with time constant of $10.6{\pm}2.0$ msec, $I_{Ai}$ of $36.9{\pm}13.9$ msec, and $I_{As}$ of $60.6{\pm}2.9$ msec at +30 mV, respectively. They also had distinct steady state inactivation range of each. Each cell expressed diverse combination of potassium currents. The cells most frequently observed were those which expressed both $I_{K1}$ and $I_{Af}$ , and they had large diameters. The cells expressing $I_{Ke}$ and expressing $I_{Ke}$ , $I_{Ai}$ , and $I_{As}$ usually had small diameters. Judging from cell diameter, capsaicin sensitivity or action potential duration, candidates for nociceptor were the cells expressing $I_{Ke}$ , expressing $I_{Ke}$ and $I_{Ai}$ , and expressing $I_{Ke}$ and $I_{As}$ . The types and distribution of potassium currents in neonatal rat DRG were similar to those of adult rat DRG (Gold et al, 1996b).


  • 주제어

    Dorsal root ganglion .   Potassium current .   Voltage clamp .   Characterization, .   Neonatal rat.  

 저자의 다른 논문

  • Kim, Ji-Mok (3)

    1. 1996 "Effects of Systemic and Focal Hypoxia on the Activities of Rostral Ventrolateral Medullary Neurons in Cats" 대한생리학회지 = Korean journal of physiology 30 (1): 105~116    
    2. 1999 "The Effects of Sera from Amyotrophic Lateral Sclerosis Patients on Neuromuscular Transmission and Calcium Channels in Mice" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (1): 101~117    
    3. 2001 "DAMGO, a ${\mu}-Opioid$ Agonist and Cholecystokinin-Octapeptide Have Dual Modulatory Effects on Capsaicin-Activated Current in Rat Dorsal Root Ganglion Neurons" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 5 (1): 71~78    
  • 정승준 (1)

  • Kim, Sang-Jeong (12)

  • 김전 (14)

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