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고양이 허파에서 산소재유입 손상을 결정하는 저산소증의 정도
Determinant Role of the Severity of Hypoxia in the Induction of Reoxygenation Injury in Cat Lung

남현정   (고려대학교 의과대학 생리학교실UU0000159  ); 김유경   (고려대학교 의과대학 생리학교실UU0000159  ); 홍승길   (고려대학교 의과대학 생리학교실UU0000159  ); 나흥식   (고려대학교 의과대학 생리학교실UU0000159  );
  • 초록

    Although reoxygenation is the best way to salvage hypoxic tissues, reduced oxygen species (ROS) generated during reoxygenation are blown to cause further tissue injuries and the induction of heat shock proteins (HSPs). The present study was undertaken to determine any causal relationship between the severity of hypoxia and the opposite outcomes, either beneficial or detrimental, of the subsequent reoxygenation by measuring the HSP72. To this aim, one group (6 male cats, $2.5{\sim}3.5\;kg$ ) was subjected to a 5-min episode of hypoventilation (H, ventilation rate: 5/min) for the induction of slight hypoxia and the other group (6 male cats, $2.4{\sim}3.7\;kg$ ) was subjected to a 5-min episode of apnea (A) for severe hypoxia. Each 3 animals from both groups received a 10-min episode of ventilation with $(95%\;O_2\;(0)$ , whereas the remainder did not. After these procedures, all animals were allowed to be ventilated within physiological range for 1, 4, or 8 hours (1H, 1HO, 4H, 4HO, 8H, 8HO, 1A, 1AO, 4A, 4AO, 8A and 8AO groups). Control animals did not receive any manipulation. The arterial blood $pCO_2$ was significantly higher just after apnea than hypoventilation, while $pCO_2$ and pH were significantly lower just after apnea than hypoventilation. Western blot analysis revealed that the magnitude of HSP72 synthesis is larger in 1H, 4H and 8H groups than in 1HO, 4H and 8HO groups, respectively. In contrast, 1AO, 4AO and 8AO groups more induced HSP72 than 1A, 4A and 8A groups, respectively. These results suggest that the reoxygenation is beneficial after slight hypoxia but detrimental after severe hypoxia.


  • 주제어

    Hypoxia .   Reoxygenation .   Heat shock protein72.  

 저자의 다른 논문

  • Nam, Hyun-Jung (4)

    1. 1997 "고양이의 기관지 동맥의 결찰이 폐조직내 열단백질 70의 생성에 미치는 효과" 결핵 및 호흡기 질환 = Tuberculosis and respiratory diseases 44 (1): 175~182    
    2. 1999 "Gradual Reperfusion Lowers the Incidence of Reperfusion-Induced Ventricular Fibrillation in a Cat Model of Regional Ischemia" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (1): 47~52    
    3. 1999 "Hypothermic Preconditioning Lowers the Incidence of Hypothermic Arrest in Neonatal Rat" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (2): 231~236    
    4. 2000 "Effect of Heat Shock Protein 72 on the Generation of Reperfusion Arrhythmias" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 4 (4): 319~324    
  • 홍승길 (10)

  • Na, Heung-Sik (6)

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