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타액분비 및 선혈류 조절에 대한 내인성 산화질소의 역할
Role of Endogenous Nitric Oxide in the Control of Salivary Secretion and Blood Flow

남상채   (전남대학교 의과대학 생리학교실UU0001112  ); 김미원   (전남대학교 의과대학 생리학교실UU0001112  ); 김원재   (전남대학교 치과대학 구강생리학교실 및 치의학연구소UU0001112  );
  • 초록

    The present study was designed to investigate whether endogenous nitric oxide(EDNO) is involved in submandibular vasodilation and salivation induced by parasympathetic nerve stimulation. Effects of $N^w$ -nitro-L-arginine-methyl ester (L-NAME) which blocks the synthesis of EDNO from L-arginine on the submandibular vasodilation and salivation induced by chords stimulation or administration of various vasodilators were examined in anesthetized cats. Effect of L-NAME on $K^+$ efflux induced by carbachol was also examined using the excised submandibular slice in vitro. In the submandibular slices, acetylcholine $(10^{-5}\;mol/L)$ or vasoactive intestinal polypeptide $(VIP,\;10^{-5}\;mol/L)$ increased $NO_2$ contents, which was Prevented by pretreatment with L-NAME. Salivary secretion in response to the chords stimulation $(3\;V,\;1\;msec,\;10{\sim}20\;Hz)$ was completely blocked by treatment with atropine(1 mg/kg). Increased blood flow response to the low frequency(1, 2, 5 Hz) stimulation was significantly reduced, whereas the blood flow induced by the higher frequency(10,20 Hz) stimulation was not affected. Lingual-arterial infusion of L-NAME(100 mg/kg) significantly diminished the vasodilatory and salivary responses to the chorda stimulation at all stimuli frequencies used. Intra-arterial infusion of L-NAME(100 mg/kg markedly diminished the vasodilatory responses to acetylcholine $(5\;{\mu}g/kg)$ , VIP $(5\;{\mu}g/kg)$ or bradykinin $(5\;{\mu}g/kg)$ . In the excised submandibular slice, $K^+$ efflux in response to carbachol $(10^{-5}\;mol/L)$ was significantly decrease by pretreatment with L-NAME $(10^{-5}\;mol/L)$ . In the isolated submandibular artery precontracted with phenylephrine $(10^{-5}\;mol/L)$ , the vasorelaxation induced by ACh $(10^{-7}\;mol/L)$ was reversed into a contraction by methylene blue $(10^{-4}\;mol/L)$ . These results suggest that EDNO may play an important role in vasodilation and secretion of the submandibular gland.


  • 주제어

    Endogenous nitric oxide .   Salivary gland .   L-NAME .   Blood flow .   Salivation.  

 저자의 다른 논문

  • 남상채 (1)

    1. 1997 "흰쥐의 Nucleus Raphe Magnus로부터 분리된 신경세포의 전기생리학적 성질" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (3): 233~240    
  • 김미원 (13)

  • Kim, Won-Jae (20)

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