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Natural product sciences v.3 no.1, 1997년, pp.59 - 70  

Inhibitory Effects of Herbal Extracts on CINC-1 Induction in LPS-Stimulated Rat Kidney Epithelioid NRK-52E cells

Ha, Joo-Young   (College of Pharmacy, Chungbuk National UniversityUU0001309  ); Kim, Young-Ki   (College of Pharmacy, Chungbuk National UniversityUU0001309  ); Lee, Kyong-Soon   (College of Pharmacy, Chungbuk National UniversityUU0001309  ); Min, Kyung-Rak   (College of Pharmacy, Chungbuk National UniversityUU0001309  ); Kim, Young-Soo   (College of Pharmacy, Chungbuk National UniversityUU0001309  );
  • 초록

    A rat chemokine, cytokine-induced neutrophil chemoattractant-1 (CINC-1) has chemotactic and activating properties to neutrophils. Rat kidney epithelioid NRK-52E cells contained 4 ng/ml of ClNC-1 as a basal level and their CINC-1 production was significantly increased by stimulation with lipopolysaccharide (LPS) of E. coli. Maximal induction of ClNC-1 was 58 ng/ml when 3 ${\mu}g/ml$ of LPS was treated to the NRK-52E cells. Inhibitory effects on CINC-1 induction in LPS-stimulated NRK-52E cells by extracts prepared from herbal medicines and wild plants in Korea were analyzed. At the final concentration of 100 ${\mu}g/ml$ , 9 species out of 304 species of herbal extracts exhibited more than 50% of inhibition on the CINC-1 induction. The active extracts prepared from Artemisia argyi, Lythrum salicaria, Machilus thunbergii, Magnolia sieboldii, Nelumbo nucifera, Prunus persica, Rubus coreanus, Sanguisorba officinalis, and Tripterygium regelii have been sequentially fractionated to obtain methylene chloride, ethyl acetate, butanol, and aqueous layers. Among solvent fractions of the active herbal extracts, methylene chloride fractions of Artemisia argyi and Magnolia sieboldii exhibited the highest inhibitory effects on CINC-1 induction in LPS-stimulated NRK-52E cells.


  • 주제어

    CINC-1 induction .   herbal extracts .   Artemisia argyi .   Magnolia sieboldii.  

 저자의 다른 논문

  • Ha, Joo-Young (2)

    1. 1996 "Inhibitory Effects of Triterpenoids on Interleukin-8/CINC-1 Induction in LPS-Stimulated Rat Peritoneal Macrophages" Natural product sciences 2 (1): 48~55    
    2. 1997 "Suppressive Effects of Triterpenoids on CINC-1 Induction in Interleukin-1{\betha}-stimulated rat fibroblast NRK-49F cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (3): 234~238    
  • Kim, Young-Ki (2)

  • 이경순 (67)

  • 민경락 (18)

  • Kim , Young-Soo (52)

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