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O/W 유제의 물리적 안정성에 대한 PVP의 영향
Effect of PVP on the Physical Stability of O/W Emulsion

오인준    (전남대학교 약학대학.약품개발연구소   ); 이미영    (전남대학교 약학대학.약품개발연구소   ); 이정민    (영진약품공업(주) 중앙연구소   ); 이용복    (전남대학교 약학대학.약품개발연구소   ); 신상철    (전남대학교 약학대학.약품개발연구소   ); 최보길    (전남대학교 약학대학.약품개발연구소   ); 김종국    (서울대학교 약학대학  );
  • 초록

    To make a stable o/w emulsion, the effects of egg lecithin as an emulsifier and polyvinylpyrrolidone (PVP) as an auxiliary emulsifier on the physical stability of emulsion were investigated. The oil-in-water emulsion system was manufactured by microfluidizer and evaluated the physical stability. Average particle size and size distribution of emulsion was measured by dynamic light scattering analyzer and interfacial tension was measured. From the interfacial tension tested, critical micelle concentration of the egg lecithin was 0.1 %w/v and optimal concentration for the preparation of emulsion was 1.0 %w/v. The mean particle size was about $0.2\;{\mu}m$ which was suitable for injections. The short-term accelerated stability studies were conducted by centrifugation, freeze-thaw method and shaking of the emulsion samples. The addition of PVP was caused the reduction in the particle size and improved the physical stability of emulsion. These results suggested that a mixed interfacial film comprising the egg lecithin and PVP was formed at the o/w interface and it was effective in preventing phase separation under thermic or mechanical stress. We used antineoplaston A10 (A10) as a model drug which is peptide and amino acid derivative having a action to the living organism against the development of neoplastic growth by a nonimmunological progress. It has a poor solubility in water and there may be a difficulty in formulation of A10. Emulsion formulation study about A10 was performed. Solubility of A10 in emulsion was about five times as high as that in water. From the results of solubility and partition coefficient, almost A10 molecules in o/w emulsion exist in the interface between oil and water.


  • 주제어

    Antineoplaston A10 .   O/W emulsions .   Egg lecithin .   Polyvinylpyrrolidone .   Particle size .   Stability.  

 저자의 다른 논문

  • Oh, In-Joon (43)

    1. 1986 "Preparation of magnetic gelatin microspheres for the targeting of drugs" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 (3): 145~152    
    2. 1987 "난용성 약물의 용출 증가 (제 3 보) -키틴 또는 키토산과의 혼합분쇄물로부터의 푸로세미드의 용출 증가-" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 17 (4): 175~181    
    3. 1988 "난용성 약물의 용출 증가(제4보) -재결정법에 의한 푸로세미드의 미세화-" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 18 (2): 55~59    
    4. 1990 "난용성 약물의 용출 증가(제5보)-포비돈과의 혼합분쇄 또는 공침에 의한 푸로세미드의 용출 증대-" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 20 (4): 193~198    
    5. 1993 "시클로덱스트린과 소염진통제 간의 포접복합체에 관한 연구(I): 2-히드록시프로필-${\beta}$-시클로덱스트린에 의한 이부프로펜의 용출 증가" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 23 (1): 11~18    
    6. 1993 "Assessment of Biodegradability of Polymeric Microspheres in vivo: Poly(DL-lactic acid), poly(L-lactic acid) and poly(DL-lactide-co-glycolid) microspheres" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 16 (4): 312~317    
    7. 1994 "Effects of D-Fructose on the Uptake of Iron by the Intestinal Brush-Border Membrane Vesicles from Rats." 藥劑學會誌 = Journal of Korean pharmaceutical sciences 24 (3): 11~18    
    8. 1995 "유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 25 (1): 55~62    
    9. 1995 "Biodegradability of $Poly({\gamma}-benzyl{\;}L-Glutamate)/Poly(Ethylene Oxide)/poly({\gamma}-benzyl{\;}L-Glutamate)$ Block Copolymer in Mice" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 18 (1): 8~11    
    10. 1995 "Stability of antineoplaston A10 in Aqueous Solution" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 18 (2): 75~78    
  • 이미영 (1)

  • 이용복 (109)

  • Shin, Sang-Chul (33)

  • Choi, Bo-Gil (24)

  • Kim, Chong-Kook (105)

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