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파모티딘-양이온 교환수지 복합체의 약물방출 특성 및 흰쥐에서의 체내동태
Drug Release Characteristics of Famotidine-Cationic Exchange Resin Complexes and Their Pharmacokinetics in Rats

신동선   (중앙대학교 약학대학UU0001197  ); 송우헌   (중앙대학교 약학대학UU0001197  ); 최영욱   (중앙대학교 약학대학UU0001197  );
  • 초록

    Ion exchange resin complexes of famotidine have been prepared by the reaction of famotidine solution with activated ion exchange resins. Complex formation efficiency between famotidine and ion exchange resin was about $80{\sim}90%$ in average, calculated by HPLC determination. Drug release characteristics from the resin complexes were evaluated by the modified percolation method. Famotidine release was dependent on the type of ion exchange resins. In the case of weakly acidic resin complexes, the cumulative released amount of famotidine was more than 90% for 1hr in pH 1.2 buffer solution. However, in the case of strongly acidic resin complexes, it was less than 5% for 3hr in the same medium. Strongly acidic resins revealed some advantages over weakly, acidic resins for overcoming instability of famotidine in gastric juice. In addition, strongly acidic resin complexes showed controlled release of famotidine in pH 6.8 buffer solution, showing the result of about 60 to 70% of drug release for 5hr. After oral administrations of famotidine-resin complexes to rats as dose of 40 mg equivalent/kg, the pharmacokinetic parameters of famotidine were obtained by model independent analysis and compared with those of famotidine solution or suspension. $C_{max}$ of famotidine-resin complex was lower than that of famotidine solution or suspension. MRT, MAT, and MDT of the complexes were greater than those of famotidine solution or suspension. From these results, it was expected that famotidine was released slowly from the complexes and absorbed continuously into systemic circulation. It was recognized that drug release from the complexes was the rate-limiting step in drug absorption, since there were close correlations between in vitro drug release and in vivo pharmacokinetic parameters.


  • 주제어

    Famotidine .   Ion exchange resins .   Resin complex .   Drug release .   Oral administration .   Pharmacokinetics .   Correlations.  

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  • 신동선 (1)

    1. 1994 "히드록시프로필셀룰로오스/카르보폴 고체분산체의 점막부착성과 팽윤 및 약물방출특성" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 24 (3): 155~165    
  • 송우헌 (6)

  • 최영욱 (20)

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