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마우스에서 Pectenotoxin 2의 급성독성 및 간대사 효소계에 주는 영향
Acute Toxicity of Pectenotoxin 2 and Its Effects on Hepatic Metabolizing Enzyme System in Mice

윤미영    (서울대학교 약학대학   ); 김영철    (서울대학교 약학대학  );
  • 초록

    Acute toxicity of pectenotoxin 2 (PTX2) was examined in mice. Treatment of mice with a toxic dose of PTX2 resulted in clinical signs such as ataxia, cyanosis and an abrupt decrease in body temperature. Histopathological studies revealed that the liver is the major target organ for PTX2. Activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and sorbitol dehydrogenase (SDH) were significantly elevated by PTX2 administration. Glucose-6-phosphatase activities were not changed by the treatment. The PTX2 treatment decreased relative liver weight without changing the body weight. The effect of PTX2 on hepatic drug metabolizing enzyme system was determined. An ip dose of PTX2 (200 $\mu$ g/kg) induced a significant decrease in the hepatic microsomal protein content. Cytochrome P-450 content, cytochrome b $_5$ content, NADPH cytochrome c reductase, aminopyrine N-demethylase activities, or hepatic glutathione content were not altered by PTX2 treatment.


  • 주제어

    Pectenotoxin 2 .   Hepatotoxicity .   Marine sponge .   Diarrhetic shellfish poisoning .   Drug metabolizing activity.  

  • 참고문헌 (14)

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  • 윤미영 (1)

    1. 1997 "해면체에서 추출한 Pectenotoxin 2의 마우스에서의 반복적인 투여에 의한 독성 및 간대사효소계에 주는 영향" 생약학회지 28 (4): 280~285    
  • Kim, Young-Chul (23)

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