본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of food science and nutrition v.2 no.4, 1997년, pp.338 - 347   피인용횟수: 1

Studies on the Distribution of Plasma Lipid Profiles and Body Fatness According to Apo E Polymorphism in Normolipidemic Korean Women

Lee, Myoung-Sook    (Department of Food and Nutrition, Sungshin Women's University  );
  • 초록

    Apo E polymorphism(e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal vairation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 89 normolipidemic healthy females, aged 19 up to 22 years. The relative frequencies of E3/3 was 0.787, E3/2 was 0.101, E3/4 allele was 0.112 and no E2/2, E2/4 and E4/4 were found. Weight, height and %LBM were elevated in E2 than those in E3&E4. No differences in the blood pressure among apo E isomers were found, otherwise the pulsation was higher in E4 than that in the others. There were no differences in plasma total-, total DL-, HDL $_3$ -, HDL $_2$ cholesterol, apo B-100 and apo A-I, However, phenotype means rank E3/2>E3/3>E3/4 in average TG levels(p E3/3>E3/2 in LDL cholesterol levels. These results were related to the correlation between atherogenic indiced (AI) such as LDL/HDL, (TC-HDL)/HDL, HDL $_3$ /HDL $_2$ . The ratio of HDL $_3$ & HDL $_2$ was significantly increased in E2 & E4 than that in E3(P=0.043). LCAT activity was not different between E2 and E3 but was highly increased in E4 (p $\beta$ -lipoprotein levels and E2 shows reciprocal effects of E4, respectively. Second, E4 allele was more atherogenic than E2 allele because the higher levels of AI such as HDL $_3$ /HDL $_2$ were criticized.


  • 주제어

    apo E polymorphism .   E3 or E4 or E2 allele .   cholesterol .   triglyceride .   atherogenic index, LDL B/E or E receptors .   LCAT .   CETP.  

  • 이 논문을 인용한 문헌 (1)

    1. 2000. "Studies on the Distribution of Plasma Lipid Profiles in Korean Hyperlipidemia according to Hyperlipoproteinemia(HLP) and Apo E Polymorphism" 韓國營養學會誌 = The Korean journal of nutrition., 33(6): 639~646     

 저자의 다른 논문

  • Lee, Myoung-Sook (25)

    1. 1999 "Apo E 유전자 변이형이 혈청지질 및 유리아미노산 농도에 미치는 영향" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition 28 (1): 225~232    
    2. 2000 "한국인 고지혈증환자에서의 혈청지질수준과 Apo E 및 고지단백혈증(HLP)의 유전자다형성 영향에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 33 (6): 639~646    
    3. 2000 "우리 나라 일부 초.중.고등학생들의 체질량지수 관련요인에 관한 분석" 대한지역사회영양학회지 = Korean journal of community nutrition 5 (3): 411~418    
    4. 2000 "남녀 초.중.고등학생의 비만도에 따른 영양소 섭취상태 및 혈청 Leptin, 아연, 구리 상태에 관한 연구" 대한지역사회영양학회지 = Korean journal of community nutrition 5 (4): 751.2~751.3    
    5. 2002 "경기지역 일부 초등학생의 성별과 비만도에 따른 영양소 섭취상태와 혈청 Leptin 및 혈청 지질에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 35 (7): 743~753    
    6. 2004 "간암세포 (HepG2 Cell)에서의 식이성 CLA(Conjugated Linoleic Acid)가 항동맥경화성 인자에 미치는 영향" 韓國營養學會誌 = The Korean journal of nutrition. 37 (3): 182~192    
    7. 2006 "Various Fatty Acids Induce Cell Damages Differently in CYP2E1-transduced HepG2 Cells, E47 Cells, Compared to C34 Cells" Nutritional sciences 9 (1): 9~13    
    8. 2006 "어유의 Docosahexaenoic Acid (DHA)가 인체혈관 내피세포(ECV304 Cells)에서의 Apoptosis에 미치는 영향" 韓國營養學會誌 = The Korean journal of nutrition. 39 (4): 357~365    
    9. 2010 "Screening of Protein Tyrosine Phosphatase 1B Inhibitory Activity from Some Vietnamese Medicinal Plants" Natural product sciences 16 (4): 239~244    
    10. 2010 "The Chemopreventive Potential and Anti-inflammatory Activities of Korean Black Ginseng in Colon26-M3.1 Carcinoma Cells and Macrophages" Journal of the Korean Society for Applied Biological Chemistry 53 (1): 101~105    

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
  • 한국식품영양과학회 : 저널
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기