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韓國營養學會誌 = The Korean journal of nutrition. v.30 no.3, 1997년, pp.299 - 306   피인용횟수: 5

폐경여성에서 비타민 K 섭취와 골밀도와의 상관관계(I) : 식이편
Correlation of Dietary Vitamin K Intakes and Bone Mineral Density in Postmenopausal Women

홍주영    (경희분당차병원 영양연구소  );
  • 초록

    Vitamin K takes part in both blood coagulation and bone metabolism via the carboxylation of glutamate residues. This study was performed to examine the relationship between dietary phylloquinone intake and bone mineral denisty(BMD) among postmenopausal Korean women (n=70, age=56). The bone mineral density of the lumbar spine and femoral neck were measured by dual X-ray absorptiometry(DEXA). Daily intakes of phylloquinone and calcium were assessed using a food frequency questionnarie. As a results, body weigh, height and body mass index were not correlated with BMD. However, the number of years since monopause and daily intakes of calcium were significantly correlated with BMD. Although daily intakes of phylloquinone were not correlated with BMD, women with relatively high BMD consumed more phylloquinone than those with lower BMD. The average daily phylloquinone and calcium intakes of the 70 postmenopausal women were 725.8ug/day, ten times more than the American RDA and 406.7mg/day, 1/2 of the American RDA for those nutrients, respectively. The major food sources for phylloquinone were seaweed, spinach and kale, whereas the food sources of calcium were milk, sardines, and yogrut. Further studies are needed to clarify the effects of dietary phyloquinone on its serum levels and BMD.


  • 주제어

    bone mineral density .   vitamin K .   postmenopause women .   undercarboxylated psteocalcin .   phylloquinone.  

  • 참고문헌 (43)

    1. 골다공증의 역학 및 위험인자 , 유명철 , 골다공증의 진단과 치료의 실제 / v.,pp.1-9,
    2. Effects of vitamin K on bone mass and bone metabolism , Vermeer,C.;Gijsbers,B.L.M.G.;Cracium,A.M.;Dooren,M.M.C.L.;Knapen,M.H. , J Nutr / v.126,pp.1187S-1191S,
    3. Phylloquinone (vitamin k₁) content of foods in the US. Food and Drug Administration's total diet study , Booth,S.L.;Sadowsk,J.A.;Pennington,J.A.T. , J Agric Food Chem / v.43,pp.1574-1579,
    4. Vitamin K₁(phylloquinone) content of foods : A provisional table , Booth,S.L.;Sadowski,J.A.;Weihrauch,J.L.;Ferland,G. , J Food Comp Anal / v.6,pp.109-120,
    5. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health , Shearer,M.J.;Bach,A.;Kohlmeier,M. , J Nutr / v.126,pp.1181S-1186S,
    6. Clinical evaluation of menatetrenone in the treatment of involutional osteoporosis-A double-blind multicenter comparative study with 1α-hydroxy vitamin D₃ , Orimo,H.;Shiraki,M.;Fujita,T.;Inoue,O.T.;Kushida,K. , J Bone Miner Res / v.7,pp.S122(abs),
    7. Dietary induced subclinical vitamin K deficiency in normal human subjects , Ferland,G.;Sadowski,J.A.;O'Brien,M.E. , J Clin Invest / v.91,pp.1761-1768,
    8. 폐경후 우리나라 여성의 영양 섭취 상태가 골다공증 발병에 미치는 영향 , 이호선;백인경;홍은실 , 대한영양사회 1995년 전국영양사학술대회지 / v.,pp.121-136,
    9. Normal carboxylation of circulating osteocalcin(bone Gla-protein) in Paget's disease of bone , Merle,B.;Delmas,P.D. , Bone Miner / v.11,pp.237-245,
    10. Recommended dietary intakes(RDI) of vitamin K in humans , Olson,J.A. , Am J Clin Nutr / v.45,pp.687-692,
    11. 감마선 측정법을 이용한 한국인 정상 골밀도치 , 양승오;이명식;곽철은;김성연;이명철;조보연;이홍규;고창순;양광자 , 대한의학협회지 / v.31,pp.1350,
    12. Measurement of K vitamins in food by high-performance liquid chromatography with fluorometric detection , Sakano,T.;Notsumot,S.;Nagaoka,T.;Morimoto,A.;Fujimoto,K.;Masuda,S.;Suzuki,Y.;Hirauchi,K. , Vitamins(Japan) / v.62,pp.393-398,
    13. Putting body weight and osteoporosis into perspective , Wardlaw,G.H. , J Clin Nutr / v.63,pp.433S-436S,
    14. Biochemical markers of bone turnover for diagnosing and monitoring of osteoporosis , 최종태 , 제 8 차 추계학술대회 초록집 / v.,pp.19-24,
    15. Vitamin K deficiency from dietary restriction in humans , Suttie,J.W.;Mummah-Schendel,L.L.;Shah,D.V.;Lyle,B.J.;Greger,J.L. , Am J Clin Nutr / v.47,pp.475-480,
    16. Osteocalcin and matrix Gla protein : Vitamin K-dependent proteins in bone , Hauschka,P.;Lian,J.B.;Cole,D.E.C.;Gundberg,C.M. , Physiological reviews / v.69,pp.990-1047,
    17. Role of vitamin K in bone metabolism , Vermeer,C.;Jie,K.S.G.;Knapen,M.H.J. , Annu Rev Nutr / v.15,pp.1-22,
    18. 폐경전 40대 한국 여성들의 영양섭취 상태와 골밀도와의 관계 , 이종호;최미숙;백인경;문수재;임승길;안광진;송영득;이현철;허갑범 , 한국영양학회지 / v.25,pp.140-149,
         
    19. Carotid intimamedia thickness in elderly women with and without qtherosclerosis of abdominal aorta , Bots,M.L.;Witteman,J.C.M.;Grobbee,D.E. , Atherosclerosis / v.102,pp.99-105,
    20. Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis : A menopulaiton-based study , Jie,K.S.G.;Bots,M.L.;Vermeer,C.;Witteman,J.C.M.;Grobbee,D.E. , Atherosclerosis / v.116,pp.117-123,
    21. Phylloquinone in plasma from elderly and young adults : Factors influencing its concentration , Sadowski,H.A.;Hood,S.J.;Dallal,G.E.;Garry,P.J. , Am J Clin Nutr / v.50,pp.100-108,
    22. Phylloquinone in plasma from elderly and young adults : factors influencing its concentration , Sadowski,J.A.;Hood,S.J.;Dallal,G.E.;Garry,P.J. , Am J Clin Nutr / v.50,pp.100-108,
    23. Impairment of gamma carboxylation of circulating osteocalcin(Bone Gla Protein) in elderly women , Plantalech,L.P.;Guillaumont,M.;Vergnaud,P.;Leclercq,M.;Delmas,P.D. , J Bone Miner Res / v.6,pp.1211-1216,
    24. Measurement of K vitamins in foods by High-Performance Liquid Chromatography with fluorometric detection , Hirauchi,K.;Sakano,T.;Notsumoto,S.;Nagaoka,T.;Morimoto,A.;Fujimoto,K.;Masuda,S.;Suzuki,Y. , Vitamins(Japan) / v.63,pp.147-151,
    25. The loss of bone mineral with aging, its relationship to risk of fracture , Smith,D.M.;Khairi,M.R.S.;Johnston,C.C. , J Clin Invest / v.56,pp.311-318,
    26. Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women , Booth,S.L.;Sokoll,L.J.;O'brien,M.E.;Tucker,K.;Dawson-Hughes,B.;Sadowski,J.A. , European J Clin Nutr / v.49,pp.832-841,
    27. 한국인 성인 남녀의 골밀도 , 용석중;임승길;허갑범;박병문;김남현 , 대한의학협회지 / v.31,pp.1350-1358,
    28. Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women , Szulc,O.;Arlot,M.;Chapuy,M.C.;Duboeuf,F.;Meunier,P.J.;Delmas,P.D. , J Bone Miner Res / v.9,pp.1591-1595,
    29. 한국 노년기 여성의 골격상태에 영향을 미치는 요인에 관한 연구 , 김혜경;윤진숙 , 한국영양학회지 / v.24,pp.30,
         
    30. Undercarboxylated osteocalcin and development of a method to determine vitamin K status , Sokoll,L.J.;O'Brien,M.E.;Camilo,M.E.;Sadowski,J.A. , Clin Chem / v.41,pp.1121-1128,
    31. 최영길 , 제 2 회 골다공증 심포지움 / v.,pp.,
    32. Physiological senile involution and pathological rarefaction of bone , Meunire,P.;Coupron,P.;Edouard,C.;Bernard,J.;Bringuir,J.;Vignon,G. , Clin Endocrinol Metab / v.2,pp.239,
    33. Influence of body and race on bone mineral density of the emidradius, hip , Desimore,D.P.;Stevens,J.;Edwards,J. , J Bone Miner Res / v.4,pp.827-830,
    34. 폐경후 여성의 골밀도에 대한 영양소 섭취실태의 영향 , 이보경;장유경;최경숙 , 한국영양학회지 / v.25,pp.642-655,
         
    35. Transport of vitamin K to bone in humans , Kohlmeier,H.;Salomon,A.;Saupe,J.;Shearer,M.J. , J Nutr / v.126,pp.1192S-1196S,
    36. The effect of vitamin K supplementation on circulating osteocalcin(Bone Gla Protein) and urinary calcium excretion , Knapen,M.H.J.;Hamulyak,K.;Vermeer,C. , Ann Intern Med / v.111,pp.1001-1005,
    37. 골다공증의 병인과 역학 , 손호영 , 제 2 회 골다공증 심포지움 / v.,pp.1-10,
    38. Phylloquinone (vitamin K₁) transport and its influence on gamma-carboxyglutamate(Gla)-residues of bone Gla-protein in patients on maintenance hemodialysis , Saupe,J.;Shearer,M.J.;Kohlmeier,M. , Am J Clin Nutr / v.58,pp.204-209,
    39. Bone turnover marker의 임상적 의의와 응용 , 임승길 , 대한골대사학회지 / v.1,pp.1-11,
    40. Review article : r-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase , Vermeer , Biochem J / v.266,pp.625-636,
    41. The association of lifetime weight and weight control patterns with mineral density in an adult community , Holbrook,T.L.;Barrett-Connor,E. , Bone and Mineral / v.20,pp.141-149,
    42. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women , Szulc,P.;Chapuy,M.C.;Meunier,P.J.;Delmas,P.D. , J Clin Invest / v.91,pp.1769-1774,
    43. Risk of bone fracture in hemodialysis patients is related to vitamin K status , Kohlmeier,M.;Saupe,J.;Shearer,M.J. , J Bone Miner Res / v.10,pp.S361,
  • 이 논문을 인용한 문헌 (5)

    1. 1998. "Bone Densities of the Middle Aged Women Residing in the City and Related Factors" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 27(6): 1279~1284     
    2. 1998. "The Relationship between Food Habit, Nutrient Intakes and Bone Mineral Density and Bone Mineral Content in Adult Women" 韓國營養學會誌 = The Korean journal of nutrition., 31(9): 1446~1456     
    3. 1999. "The Study of Correlation between Serum Vitamin K Concentration and Bone Metabolism in Postmenopausal Women" 韓國營養學會誌 = The Korean journal of nutrition., 32(3): 287~295     
    4. 1999. "The Effects of Vitamin K Supplements on Serum Osteocalcin Caraboxylation in Postmenopausal Women" 韓國營養學會誌 = The Korean journal of nutrition., 32(6): 726~731     
    5. 2004. "A Study of Factors Affecting Bone Mineral Density in Children: Anthropometric Measurements, Socioeconomic Factors, Family History, and Other Environmental Factors" 韓國營養學會誌 = The Korean journal of nutrition., 37(1): 52~60     

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