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산모의 요오드섭취가 산후 갑상선염 발현에 미치는 영향
The Effects of Dietary Iodine Intake on the Postpartum Thyroiditis(PPT) Manifestation

조여원    (경희대학교 식품영양학과  );
  • 초록

    Iodine-rich seaweed soup has been traditionally supplied to postpartum women in Korea. This dietary habit might introduce over-intake of iodine above the recommended requirements, and might provoke postpartum thyroid dysfunction. Although the response to excess iodine intake is highly variable, goiter, hyperthyroidism, hypothyroidism, and thyroiditis could follow the daily intake of 1,500 $\mu\textrm{g}$ of iodine. A few studies are available concerning iodine toxicity in Korea. The purpose of this study was to investigate the relationships between the dietary intake of iodine and thyroid function change as well as the incidence of postpartum thyroiditis. One hundred and thirty-seven postpartum women who had experienced normal deliveries were studied. Dietary intake of iodine and excretion concentration of iodine in breast milk and maternal urine were measured . Serum T $_3$ , T $_4$ , TSH, anti-thyroglobulin antibody, and anti-microsomal antibody were anlayzed 1 week before delivery and 1, 6, 12, and24 weeks after delivery. Iodine intake was analyzed by one-to-one interviews using 24-hr recall and a food frequncy questionnaire. The result showed that the intake of dietary iodine before delivery and 1 and24 weeks after delivery were 483 $\mu\textrm{g}$ /day, 3367 $\mu\textrm{g}$ /day, and 1069 $\mu\textrm{g}$ /day, respectively. The concentration of iodine in urine at the first week after delivery was 63 $\mu\textrm{g}$ /dL, and 23.9 $\mu\textrm{g}$ /dL in breast milk . The levels of serum T $_3$ and T $_4$ before delivery were 2.01ng/mL and 11.49 $\mu\textrm{g}$ U/dL, respectively, showing that the levels were gradually dropping to normal values after delivery. Positive serum anti-thyroglobulin antibody and anti-microsomal antibody appeared in 3 cases. After a 24 week follow-up period , 6 women(10.3%) experienced cases of postpartum thyroiditis, 5 of which were cases of hyperthyroidism and one of which was a case of hypothyroidism. These figures of postpartum thyroiditis are similar to those of other countries.


  • 주제어

    iodine .   PPT .   $T_3$ .   $T_4$ .   TSH .   anti-thyroglobulin antibody .   anti-microsomal antibody.  

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