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韓國營養學會誌 = The Korean journal of nutrition. v.30 no.8, 1997년, pp.936 - 951   피인용횟수: 1

건강한 젊은 여성의 Apolipoprotein E 의 다형성 , 식이 지방 섭취, 혈청 지단백 농도와 적혈구 막의 지방산 조성과의 관계
Relationship Among Apolopoprotein E Phenotypes, Dietary Fat, Serum Lipoprotein Concentrations and Erythrocyte Membrane Fatty Acid Composition in Young Healthy Women

박선민    (호서대학교 자연과학대학 식품영양학과  );
  • 초록

    As fat consumption has increased in Korea , serum cholesterol concentrations have risen and the prevalence of atherosclerosis increased. The aim of the present study was to investigate the association among apolipoprotein E (Apo E) phenotypes, dietary fat consumption, plasma lipoprotein levels and fatty acid compositions of red blood cells in young healthy women. Seventy-one percent of participants had Apo E3/3, 14.9 percent had ApoE3/2 , 11.8% had Apo E4/3 and 1.2% had Apo E4.2. The subjects daily consumed approximately 1760kcal containing 29 energy % of fat. The ratio of polyunsaturated fat to saturated fat in a diet was 0. 73 . There were no significant differences of nutrient intakes according to Apo E phenotypes. Total cholesterol concentrations of subjects averaged approximately 160mg/dl , but 12 percent of them had over 200mg/dl, which is higher than the range recommended by the National Cholesterol Deucation Program. Notably, most subjects with 210mg/dl had Apo E4 isoforms. Subjects with Apo E4 isoforms had significantly higher total and LDL-cholesterol concentrations than those with Apo E3/2. Also subjects carrying Apo E4 isoforms tended to accumulated more fat in the body. Their BMI , WHR and arm fat area appeared to be how can arm fat area be greater no you mean grater, please check work vsage than subjects with Apo E3 isoforms, but not significantly. Fat intakes slightly influenced serum cholesterol levels. Myristic aicd intakes were positively correlated to serum total and LDL-choelsterol levels. Polyunsaturated fatty acid intakes were negatively correlated to serum total choelsterollevels. The results of 소냐 study suggest that , people with Apo E4 isoforms need to prevent the raising of serum total and LDL -cholesterol concentrations by reducing calorie and fat intakes and by maintaining a normal weight.

  • 주제어

    apolopoprotein E phenotypes .   dietary fat .   premenopausal women .   serum lipoproteins.  

  • 참고문헌 (56)

    1. Relation of high density llipoprotein subfractions ad apolipoprotein E isoforms to coronary disease , Wilson,P.W. , Clin Chem / v.41,pp.165-169,
    2. 젊은 성인 남자의 체지방량 및 분포가 성인병 발생 위험 요인에 미치는 영향 , 조은희;김순경 , 한국영양학회지 / v.28,pp.460-470,
    3. Polymorphism at the apo E locus in relation to risk of coronary disease , Cumming,A.M. , Clin Genet / v.25,pp.310-313,
    4. Trends in individual consumption of dietary fat in the United States. 1920-1984 , A.M.Stephen;N.J.Wald , Am J Clin Nutr / v.52,pp.457-464,
    5. 여대생의 영양 섭취상태 및 혈액 성상에 관한 연구-제 1보 혈청 지질 성분을 중심으로- , 홍순명;백금주(등) , 한국영양학회지 / v.26,pp.338-346,
    6. 지방 섭취 증가가 일부 젊은 여성의 혈장 지단백 조성에 미치는 영향 , 허영란;임현숙 , 한국영양학회지 / v.28,pp.697-705,
    7. Report of the National Cholesterol Education Program the expert panel on detection, evaluation and treatment of high blood cholesterol in adults , Arch Intern Med / v.148,pp.36-39,
    8. Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4 , Muros,M.;Rodriguez-Ferrer Carmen , Atherosclerosis / v.121,pp.13-21,
    9. Relation of high density lipoprotein subfractions and apolipoprotein E isoforms to coronary disease , Wilson,P.W. , Clin Chem / v.41,pp.165-169,
    10. Fatty acid composition of serum cholesterol esters, and erythrocyte and platelet membranes as indicators of long-term adherence to fat modified diets , Sarkkinen,E.S.;Agren,J.J.;Ahola,I.;Ovaskainen,M.L.;Uusitupa,M.I.J. , Am J Clin Nutr / v.59,pp.364-370,
    11. Dietary fatty acid thresholds and cholesterolemia , Hayes,K.C.;Khosla,P. , FASEB J / v.6,pp.2600-2607,
    12. Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes , Prosco,D.;Filippini,M.;Francalanci,I.;Paniccia,R.;Gensini,G.F.;Abbate,R.;Gastone,G.;Serneri,N. , Am J Clin Nutr / v.63,pp.9225-9232,
    13. Do individual saturated fatty acids have different effects on metabolism of serum lipoproteins? , Snook,J.S.;Park,S. , Metabolism / v.,pp.,
    14. Lee,R.D.;Nieman,D.C. , Nutritional assessment(2nd) / v.,pp.128-140,
    15. physical activity assessment methodology in the Five-City Project , Sallis,J.F.;Haskell,W.;Wood,P. , Am J Epidemiol / v.121,pp.9-106,
    16. Rapid method for determination of total fatty acid content and composition of feedstuffs and feces , Sukhija,P.S.;Palmquist,D.L. , J Agricult Food Chem / v.36,pp.1202-1206,
    17. 바람직한 지방산 섭취형태 , 장남수 , 한국영양학회지 / v.26,pp.486-503,
    18. Human Apolipoprotein E. The complete amino acid sequence , Rall,S.C.Jr.;Weisgraber,K.H.;Mahley,R.W. , J Biol Chem / v.257,pp.4171-4178,
    19. 지방 섭취 양상에 따른 연령별 건강 상태에 관한 동서양의 비교 연구 , 한국 과학 재단 , KOSEF 90-0700-18 / v.,pp.,
    20. Apolipoprotein E synthesis in human kidney, adrenal gland and liver , Blue,M.L.;Williams,D.L.;Zucker,S.;Khan,S.A.;Blum,C. , Proc Natl Acad Sci USA / v.80,pp.283-287,
    21. Reciprocal effects of apo E alleles(e2 & e4) on plasma lipid levels in normolipidemic subjects , Eto,M. , Clin Genet / v.29,pp.477-484,
    22. 한국 일부 여대생의 식이 지방산과 혈장 지질 및 혈장 및 적혈구 지방산 조성과의 관계 , 김양희;백희영 , 한국영양학회지 / v.27,pp.109-117,
    23. Relative effects of saturated fatty acids high in meat, dairy products, and tropical oils on serum lipoproteins and LDL degradation by mononuclear cells in healthy males , Park,S.;Snook,J.T.(et al.) , Metabolism / v.45,pp.550-558,
    24. 농촌진흥청 , 식품 성분표(4차 개정판) / v.,pp.,
    25. Dextran sulfate-Mg 2+ precipitation procedure for quantitation of high density lipoprotein cholesterol , Warnick,G.R.;Benderson,J.;Albers,J.J. , Clin Chem / v.28,pp.1379-1388,
    26. Hydroperoxides selectively inhibit human erythrocyte membrane enzyme , Moore,R.B.;Brummitt,M.L.;Mankad,V.N. , Arch Biochem Biophy / v.2733,pp.527,
    27. Synthesis, intracellular processing and signal peptide of human apo E , Zannis,V.I.;McPherson,J.;Goldberger,G.;Karathanasis,S.;Breslow,J.L. , J Biol Chem / v.259,pp.5495-5499,
    28. 일부 젊은 여성의 지질 섭취와 혈장 지단백 및 지방산 조성에 관한 연구 , 김미정;임현숙 , 한국영양학회지 / v.28,pp.595-601,
    29. Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apo E1 and apo E5 isoforms , Ordovas,J.M.;Litwack-Klein,L.;Wilson,P.W.F.;Schaefer,M.M.;Schaefer,E.J. , J Lipid Res / v.28,pp.371-380,
    30. Apolipoprotein E polymorphism alters the association between body fatness and plasma lipoproteins in women , Pouliot,M.C.;Despres,J.P.;Moorjani,S.;Lupien,P.J.;Tremblay,A.;Bouchard,C. , Journal of Lipid Research / v.31,pp.1023-1029,
    31. Does a diet high in corn oil lower LDL cholesterol levels in women via an effect on LDL receptor activity? , Park,S.;Snook,J.T. , J Nutr Biochem / v.6,pp.88,
    32. 연령 증가에 따른 한국 성인의 영양 섭취상태가 지방대사에 미치는 영향 , 이혜양;김숙희 , 한국영양학회지 / v.27,pp.46-52,
    33. Lipid extraction , Folch,J.M.;Lee,G.H.;Stanley,S. , J Biol Chem / v.226,pp.497,
    34. Distribution of apolipoprotein A-I, C-II, C-III and E mRNA in fetal human tissues , Zannis,V.I.;Cole,F.S.;Jackson,C.L.;Kurnit,D.M.;Karathanasis,S. , Biochemistry / v.24,pp.4450-4455,
    35. Lohman,T.G.;Roche,A.F. , Anthropometric standardization reference manual / v.,pp.,
    36. Studies apo E genetic isoforms and their phenotypes among the chinese populations , Wang,K. , Acta Acad Med Science / v.8,pp.198,
    37. Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis , Miller,N.E. , Review / v.113,pp.589-597,
    38. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men , Rimm,E.B.;Stampfer,M.J.(et al.) , Am J Epidemiol / v.141,pp.1117-1127,
    39. 체지방량 추정을 위한 초음파피지후계와 caliper의 비교 , 정진욱;이성국(등) , 한국영양학회지 / v.28,pp.282-290,
    40. Diet and coronary heart disease : beyond dietary fats and low-density-lipoprotein cholesterol , Fraser,G.E. , Am J Clin Nutr / v.59,pp.1117S-1123S,
    41. Mayo Clinic Reference Values. Plus Personal Communications, 1977 , Ellefson,R.D.;Palumbo,P.J.;Pemberton,C.M.(et al.);Moxness,K.E.(et al.) , Diet Manual(6th ed.) / v.,pp.82-83,
    42. 식이 섭취조사 방법과 조사일수에 따른 한국 젊은 여성의 영양소 섭취수준의 비교 , 오세영;이혜영;백희영 , 한국영양학회지 / v.29,pp.1021-1027,
    43. 한국과 미국의 식품 섭취조사 방법 및 지방 섭취량의 비교 , 박선민 , 한국영양학회지 / v.29,pp.1121-1132,
    44. 한국영양학회 , 한국인영양권장량(6차 개정판) / v.,pp.,
    45. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge , Friedewald,W.T.;Levy,P.;Wood,R.I.;Fredickson,D.S. , Clin Chem / v.18,pp.499-502,
    46. USDA. Composition of foods , Agricultural Handbook / v.,pp.,
    47. Apolipoprotein E2 & E4 alleles influence on the distribution of the human plasma lipid profiles in normolipidemic Korean women , Lee,M.S. , Korean J Nutrition / v.29,pp.642-650,
    48. Apolipoprotein E polymorphism in American Indians and its relation to plasma lipoproteins and diabetes. The strong heart study , Kataoka,S.;Robbins,D.C.;Cowan,L.D.;Go, Cowan;Yeh,J.L.;Devereux,R.B.;Fabsitz,R.R.;Lee,E.T.;Welty,T.K.;Howard,B.V. , Arterioscler Thromb Vasc Biol / v.16,pp.918-925,
    49. Quantitative determination of serum triglycerides by the use of enzymes , Bucolo,G.;David,H. , Clin Chem / v.20,pp.470-475,
    50. Assignment of the human gene for the low density lipoprotein receptor to chromosome 19 : synthesis of a receptor, a ligand and a genetic disease , Francke,U.;Brown,M.S.;Goldstein,J.L. , Proc Natl Acad Sci USA / v.81,pp.2826-2830,
    51. Abnormal lipoprotein receptor-binding activity of the human apoprotein due to cystein-arginine interchange at a single site , Weisgraber,K.H.;Mahley,R.W.;Innerarity,T.L. , J Biol Chem / v.257,pp.2518-2521,
    52. Two independent lipoprotein receptors on hepatic membranes of dog, swine and man. Apo B,E and apo E receptors , Mahley,R.W.;Hui,D.Y.;Innerarity,T.L.;Weisgraber,K.H. , J Clin Invest / v.68,pp.1197-1206,
    53. 보건 사회부 , '93 국민영양조사 보고서 / v.,pp.,
    54. Enzymatic determination of total serum cholesterol , Allain,C.C.;Poon,L.S. , Clin Chem / v.20,pp.470-475,
    55. Anthropometric measurement of muscle mass revised equation for calculating bone free arm muscle area , Heymsfield,S.B.;McManus,C. , Am J Clin Nutr / v.36,pp.680-690,
    56. 바람직한 지방산 섭취 , 이양자 , 대한영양사회학술 쎄미나 / v.,pp.,
  • 이 논문을 인용한 문헌 (1)

    1. 1999. "Relationships between Fatty Acid Intake and Serum Lipids in Postmenopausal Women" 韓國營養學會誌 = The Korean journal of nutrition., 32(4): 437~447     

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