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Journal of microbiology and biotechnology v.7 no.1, 1997년, pp.52 - 55   피인용횟수: 14

Immunostimulating Activity of Polysaccharides from Mycelia of Phellinus linteus Grown under Different Culture Conditions

Lee, Jae-Hoon   (Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science. and TechnologyCC0186997  ); Cho, Soo-Muk   (Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science. and TechnologyCC0186997  ); Kim, Hwan-Mook   (Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science. and TechnologyCC0186997  ); Hong, Nam-Doo   (Bangchon Natural Products Research Institute, HanKookSinYak Pharm. Co. Ltd.  ); Yoo, Ick-Dong   (Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science. and TechnologyCC0186997  );
  • 초록

    Polysaccharides were extracted from mycelia of Phellinus linteus grown under different culture conditions. The in vitro immunostimulating activity was measured by plaque-forming cell (PFC) assay. The activity of the polysaccharides was different from that of mycelia from which was extracted. The number of PFC's ranged from 40 to 600 depending on the media. When P. linteus was cultured on a medium with mannose or starch as a sole carbon source, the fungus produced polysaccharide with the highest activity of 960 PFC. Activity was therefore increased by $50%$ compared with polysaccharide which was extracted from mycelia grown on medium with glucose. pH had little effect on the change in activity. All polysaccharides on media with different pH stimulated about 600 PFC. These results suggest that activity could be increased by polysaccharide modification through changes in physiological conditions.


  • 주제어

    Phellinus linteus .   Polysaccharides .   immunostimulating activity.  

  • 이 논문을 인용한 문헌 (14)

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