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Immunosuppressive Characteristics of Oligomycin Derivatives Produced by Streptomyces lydicus MCY-524

Lee, Sang-Yong   (Department of Microbiology, Kyungpook National UniversityUU0000096  ); Han, Sang-Bae   (Korea Research Institute of Bioscience and Biotechnology, KISTCC0186997  ); Kim, Hang-Sub   (Korea Research Institute of Bioscience and Biotechnology, KISTCC0186997  ); Kim, Young-Ho   (College of Pharmacy, Chungnam National UniversityUU0001302  ); Kim, Hwan-Mook   (Korea Research Institute of Bioscience and Biotechnology, KISTCC0186997  ); Kim, Chang-Jin   (Korea Research Institute of Bioscience and Biotechnology, KISTCC0186997  ); Hong, Soon-Duck   (Department of Microbiology, Kyungpook National UniversityUU0000096  ); Lee, Jung-Joon   (Korea Research Institute of Bioscience and Biotechnology, KISTCC0186997  );
  • 초록

    A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 ${\mu}g$ /ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.


  • 주제어

    immunosuppressant activities .   homooligomycin E .   Streptomyces lydicus.  

 저자의 다른 논문

  • 이상용 (4)

    1. 1993 "Nucleotide Sequencing Analysis of a Gene Coding for 3-Isopropylmalate Dehydrogenase of Kluyveromyces fragilis" Journal of microbiology and biotechnology 3 (2): 91~94    
    2. 1996 "방선균주 7489가 생산하는 DNA Topoisomerase I 저해제에 관한 연구" 산업미생물학회지 = Korean journal of applied microbiology and biotechnology 24 (1): 101~104    
    3. 1997 "Immunosuppressive Activity of Elaiophylins" Journal of microbiology and biotechnology 7 (4): 272~277    
    4. 1997 "Production of Elaiophylin by the Strain MCY-846 in a Submerged Culture" Journal of microbiology and biotechnology 7 (4): 278~281    
  • 김항섭 (5)

  • Kim , Young-Ho (114)

  • 김창진 (24)

  • Hong, Soon-Duck (32)

  • Lee, Jung-Joon (23)

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