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Depression of $Ca^{2+}$ Influx in Complement C5a-stimulated Neutrophils by Calmodulin Inhibitors

Ham, Dong-Suk   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Kim, Hyun-Ho   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Han, Eun-Sook   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Lee, Chung-Soo   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  );
  • 초록

    Role of $Ca^{2+}$ /calmodulin complex in intracellular $Ca^{2+}$ mobilization in neutrophils has not been clearly elucidated. In this study, effects of chlorpromazine, trifluoperazine and imipramine on the intracellular $Ca^{2+}$ mobilization, including $Ca^{2+}$ influx, in C5a-activated neutrophils were investigated. Complement C5a- stimulated superoxide production and myeloperoxidase release in neutrophils were inhibited by chlorpromazine, trifluoperazine and imipramine, except no effect of imipramine on myeloperoxidase release. A C5a-elicited elevation of [ $Ca^{2+}$ ]i in neutrophils was inhibited by chlopromazine, trifluoperazine, imipramine, staurosporine, genistein, EGTA, and verapamil but not affected by pertussis toxin. The intracellular $Ca^{2+}$ release in C5a-activated neutrophils was not affected by chlorpromazine and imipramine. Chlorpromazine and imipramine inhibited $Mn^{2+}$ influx by C5a-activated neutrophils. Thapsigargin-evoked $Ca^{2+}$ entry was inhibited by chlorpromazine, trifluoperazine, imipramine, genistein, EGTA and verapamil, while the effect of staurosporine was not detected. The results suggest that $Ca^{2+}$ /calmodulin complex is involved in the activation process of neutrophils. The depressive action of calmodulin inhibitors on the elevation of cytosolic $Ca^{2+}$ level in C5a-activated neutrophils appears to be accomplished by inhibition of $Ca^{2+}$ influx from the extracellular medium.


  • 주제어

    Calmodulin inhibitors .   Intracellular $Ca^{2+}$ mobilization .   Complement C5a .   Neutrophils.  

 저자의 다른 논문

  • Ham, Dong-Suk (1)

    1. 1996 "Protein Kinase 억제제 첨가 후 Platelet-Activating Factor에 의하여 자극된 호중구반응의 변경" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 32 (1): 103~112    
  • Kim, Hyun-Ho (1)

  • 한은숙 (16)

  • Lee, Chung-Soo (28)

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