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Comparison of Somatostatin and Morphine Action on the Responses of Wide Dynamic Range Cells in the Dorsal Horn to Peripheral Noxious Mechanical and Heat Stimulation in Cats

Jung, Sung-Jun   (Department of Physiology, Dankook University College of MedicineUU0000336  ); Choi, Young-In   (Department of Physiology and Biophysics, Seoul National University College of MedicineUU0000691  ); Kim, Jun   (Department of Physiology and Biophysics, Seoul National University College of MedicineUU0000691  );
  • 초록

    The purpose of present study was to compare the effects of somatostatin (SOM) and morphine (Mor) on the responses of wide dynamic range (WDR) cells to peripheral noxious stimulation. Single neuronal activity was recorded with a carbon-filament electrode at the lumbosacral enlargement of cat spinal cord. After identifying WDR cells, their responses to peripheral noxious mechanical or thermal stimuli were characterized and the effects of SOM and Mor, applied either iontophoretically or intrathecally, were studied. In most cells SOM and Mor suppressed noxious stimulus-evoked WDR neuronal activity, though a few WDR neurons showed no change or were excited by SOM and Mor. Systemically applied naloxone, a non-specific opioid antagonist, always reversed the Mor induced suppression of neuronal activity evoked by noxious mechanical stimuli, but did not always reverse the suppression of neuronal activity elicited by SOM. The suppressive effect of Mor on thermal stimulus-evoked neuronal activity was partially reversed by naloxone, while that of SOM were not reversed at all. The above results suggest that both Mor and SOM exert an inhibitory effect on thermal and mechanical stimulus-evoked WDR neuronal activity in cat spinal dorsal horn, but the mechanisms are dependent upon the functional populations of dorsal horn nociceptive neurons.


  • 주제어

    WDR cells .   Somatostatin .   Morphine .   Naloxone .   Mechanical and thermal noxious stimuli.  

 저자의 다른 논문

  • Jung, Sung-Jun (4)

    1. 1999 "The Effects of Sera from Amyotrophic Lateral Sclerosis Patients on Neuromuscular Transmission and Calcium Channels in Mice" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (1): 101~117    
    2. 1999 "The Role of Somatostatin in Nociceptive Processing of the Spinal Cord in Anesthetized Cats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (4): 365~373    
    3. 2000 "Responses of Dorsal Horn Neurons to Peripheral Chemical Stimulation in the Spinal Cord of Anesthetized Cats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 4 (1): 15~24    
    4. 2001 "DAMGO, a ${\mu}-Opioid$ Agonist and Cholecystokinin-Octapeptide Have Dual Modulatory Effects on Capsaicin-Activated Current in Rat Dorsal Root Ganglion Neurons" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 5 (1): 71~78    
  • Kim, Jun (16)

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