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Electrolysis of Physiological Salt Solution Generates a Factor that Relaxes Vascular Smooth Muscle

Song, Pil-Oh   (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National UniversityUU0000114  ); Chang, Ki-Churl   (Department of Pharmacology, Cardiovascular Research Institute, College of Medicine, Gyeongsang National UniversityUU0000114  );
  • 초록

    Oxygen-derived free radicals have been implicated in many important functions in the biological system. Electrical field stimulation (EFS) causes arterial relaxation in animal models. We found that EFS applied to neither muscle nor nerve but to Krebs solution caused a relaxation of rat aorta that had been contracted with phenylephrine. In the present study, therefore, we investigated the characteristics of this EIRF (electrolysis-induced relaxing factor) using rat isolated aorta. Results indicated that EIRF acts irrespective of the presence of endothelium. EIRF shows positive Griess reaction and is diffusible and quite stable. EIRF-induced relaxation was stronger on PE-contracted aorta than on KCl-contracted one, and inhibited by the pretreatment with methylene blue. Zaprinast, a cGMP-specific phosphodiesterase inhibitor, potentiated the EIRF-induced relaxation. $N^G-nitro-L-arginine$ , NO synthase inhibitor, did not inhibit the EIRF-induced relaxation. Deferroxamine, but not ascorbic acid, DMSO potentiated the EIRF-induced relaxation. These results indicate that electrolysis of Krebs solution produces a factor that relaxes vascular smooth muscle via cGMP-mediated mechanism.


  • 주제어

    Vascular relaxation .   cGMP .   Electrolysis .   Nitric oxygen .   Oxygen radicals.  

 저자의 다른 논문

  • Chang, Ki-Churl (26)

    1. 1983 "적출 가토 심장에 있어서 수축빈도-수축력 상관관계에 대한 Higenamine의 강심 효과" 대한약리학잡지 19 (2): 9~16    
    2. 1986 "Higenamine의 합성 및 가토의 심혈관계에 미치는 영향 : 베타-아드레날린성 효능 약물" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 22 (2): 96~104    
    3. 1989 "개 신동맥 내피세포의 무스카린성 및 알파 아드레날린성 수용체에 대한 작용" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 25 (1): 43~51    
    4. 1991 "GS354, GS389: 새로운 칼슘 길항제" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 27 (1): 45~52    
    5. 1994 "GS 283의 평활근 억제 작용기전" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 30 (1): 101~109    
    6. 1994 "동맥경화 예방과 치료를 위한 연구시도: Nitric Oxide의 역활 -광 유도 nitric oxide(PIANO)의 혈관이완에 따른 cyclic GMP의 증가" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 30 (3): 331~336    
    7. 1994 "Another Evidence for Nitric Oxide as Mediator of Relaxation of Isolated Rabbit and Human Corpus Cavernosum" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2 (2): 136~140    
    8. 1995 "심근세포 및 혈관 평활근에 대한 Nitric Oxide 작용의 민감성의 차이" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (3): 279~284    
    9. 1995 "Another Evidence for Nitric Oxide as One of the Mediators of the Rat gastric Fundus in Response to NANC-Mediated Relaxation" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 3 (2): 149~153    
    10. 1996 "흰쥐 기관평활근에 대한 GS 386의 칼슘억제 및 포스포디에스테라제 억제 작용" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 32 (3): 373~380    

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