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Characteristic Intracelluar Response to Lidocaine And MK-801 of Hippocampal Neurons: An In Vivo Intracellular Neuron Recording Study

Choi, Byung-Ju   (Department of Dental Pharmacology, Kyungpook National University School of DentistryUU0000096  ); Cho, Jin-Hwa   (Department of Dental Pharmacology, Kyungpook National University School of DentistryUU0000096  );
  • 초록

    This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of $2.4{\pm}0.9$ Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of $3.28{\pm}5.7\;M{\Omega}$ and a membrane time constant of $7.4{\pm}1.8$ ms. These neurons exhibited $2.4{\pm}0.2$ ms spike durations, which were similar to the average spike duration recorded in the neurons of the control group. Slightly less than half of these neurons were firing spontaneously with an average discharge rate of $2.4{\pm}1.1$ Hz. The average peak amplitude of the AHP following the spikes in these groups was $7.4{\pm}0.6$ mV with respect to the resting membrane potential. Cells in MK-801 and lidocaine treated group (5 mg/kg, i.c.v.) had an average input resistance of $3.45{\pm}6.0\;M{\Omega}$ and an average time constant of $8.0{\pm}1.4$ ms. The cells were firing spontaneously at an average discharge rate of $0.6{\pm}0.4$ Hz. Upon depolarization of the membrane by 0.8 nA for 400 ms, all of the tested cells exhibited accommodation of spike discharge. The most common synaptic response contained an EPSP followed by early-IPSP and late-IPSP. Analysis of the voltage dependence revealed that the early-IPSP and late-IPSP were putative $Cl^--and\;K^+-dependent$ , respectively. Systemic injection of the NMDA receptor blocker, MK-801, did not block synaptic responses to the stimulation of the commissural pathway. No significant modifications of EPSP, early-IPSP, or late-IPSP components were detected in the MK-801 and/or lidocaine treated group. These results suggest that MK-801 and lidocaine manifest their CNS effects through firing pattern of hippocampal pyramidal cells and neural network pattern by changing the synaptic efficacy and cellular membrane properties.


  • 주제어

    Lidocaine .   MK-801 .   Hippocampus .   Local anesthetics .   Intracellular recording .   Commissural pathway.  

 저자의 다른 논문

  • Choi, Byung-Ju (19)

    1. 1996 "리도카인이 흰쥐 피질의 체성감각 유발전위에 미치는 영향" 大韓小兒齒科學會誌 = Journal of the Korean academy of pediatric dentistry 23 (3): 582~592    
    2. 1997 "MC3T3-E1세포의 ALP activity에 대한 IGF-I의 영향" 대한치주과학회지 = The journal of Korean academy of periodontology 27 (4): 669~684    
    3. 1997 "MC3T3-E1 세포의 ALP activity에 대한 PDGF-BB의 영향" 대한치주과학회지 = The journal of Korean academy of periodontology 27 (4): 685~700    
    4. 1998 "해마 theta 리듬과 pyramidal neuron의 세포내 특성과의 상관관계" 大韓小兒齒科學會誌 = Journal of the Korean academy of pediatric dentistry 25 (4): 671~682    
    5. 1999 "마취된 흰쥐 해마신경세포에서 Neurobiotin 이온주입으로 인한 신경세포의 생리적 특성의 변화" 大韓小兒齒科學會誌 = Journal of the Korean academy of pediatric dentistry 26 (2): 218~231    
    6. 2000 "흰쥐 안면신경핵 세포의 전기생리학적 및 형태학적 특성" 大韓小兒齒科學會誌 = Journal of the Korean academy of pediatric dentistry 27 (3): 400~409    
    7. 2000 "생체내 흰쥐 해마 CA1 세포에서 가바성 억제에 대한 전기생리학 특성" 大韓小兒齒科學會誌 = Journal of the Korean academy of pediatric dentistry 27 (1): 7~14    
    8. 2004 "Interhemispheric Modulation on Afferent Sensory Transmission to the Ventral Posterior Medial Thalamus by Contralateral Primary Somatosensory Cortex" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 8 (3): 129~132    
    9. 2005 "Intra-articular Injection of $IL-1{\beta}$ Facilitated Formalin-induced Temporomandibular Joint Pain in Freely Moving Rats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 9 (1): 23~27    
    10. 2005 "Differential Effects of Typical and Atypical Antipsychotics on MK-801-induced EEG Changes in Rats" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 9 (1): 17~22    
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