본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Effects of Prostaglandin $E_2$ on the Spontaneous Contractions and Electrical Activities of the Antral Circular Muscle in Guinea-pig Stomach

Kim, Jong-Yoon   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  ); Kim, Sung-Joon   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  ); Kang, Tong-Mook   (Samsung Biomedical Research InstituteCC0102064  ); Lee, Sang-Jin   (Department of Physiology, Chungbuk National University College of MedicineUU0016427  ); Jun, Jae-Yeoul   (Department of Physiology, Chosun University College of MedicineUU0001180  ); So, In-Suk   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  ); Kim, Ki-Whan   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  );
  • 초록

    The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of prostaglandin $E_2$ ( $PGE_2$ ) on the contractile and electrical activities of antral smooth muscles in guinea-pig stomach, using an intracellular recording technique. To elucidate the underlying mechanism for its effect on contractility, ionic currents were also measured using a whole-cell patch clamp method. The basal tone by $PGE_2$ was variable, whereas the magnitude of phasic contractions was reduced ( $19.0{\pm}2.1%$ , n=19). The resting membrane potentials were hyperpolarized ( $-4.4{\pm}0.5%$ mV, n=10), and plateau potentials were lowered ( $-2.9{\pm}0.5%$ mV, n=10). In most cases, however, the initial peak potentials of slow waves were depolarized more by $PGE_2$ than those of control. The frequency of the slows wave was increased from $5.7{\pm}0.2$ cycles/min to $6.5{\pm}0.2$ (n=22). Voltage-operated $Ca^{2+}$ currents were decreased by $PGE_2$ (n=5). Voltage-operated $K^+$ currents, both Ca-dependent and Ca-independent, were increased (n=5). These results suggest that $PGE_2$ plays an important role in the modulation of gastric smooth muscle activities, and its inhibitory effects on the contractility and activities of slow waves are resulted from both decrease of $Ca^{2+}$ currents and increase of $K^+$ currents.


  • 주제어

    $PGE_2$ .   Gastric smooth muscle .   Slow waves .   $K^+$ current .   $Ca^{2+}$ current.  

 저자의 다른 논문

  • Kim, Sung Joon (18)

    1. 1993 "Effects of Noradrenaline on the Spontaneous Contraction and Ionic Current in the Antral Circular Muscle of Guinea-pig Stomach" 대한생리학회지 = Korean journal of physiology 27 (2): 115~122    
    2. 1993 "Effect of Dopamine on the $Ca^{2+}\;-dependent\;K^+\;currents$ in Isolated Single Gastric Myocytes of the Guinea-pig" 대한생리학회지 = Korean journal of physiology 27 (2): 139~150    
    3. 1994 "Effects of Lemakalim, a Potassium Channel Opener, on the Contractility and Electrical Activity of the Antral Circular Muscle in Guinea-Pig Stomach" 대한생리학회지 = Korean journal of physiology 28 (1): 37~50    
    4. 1994 "The Excitatory Mechanism of Substance P in the Antral Circular Muscle of Guinea Pig Stomach" 대한생리학회지 = Korean journal of physiology 28 (1): 51~59    
    5. 1995 "Contractile and Electrical Responses of Guinea-pig Gastric Smooth Muscle to Bradykinin" 대한생리학회지 = Korean journal of physiology 29 (2): 233~241    
    6. 1997 "Effects of Arachidonic Acid on the Calcium Channel Current $(I_{Ba})$ and on the Osmotic Stretch-induced Increase of $I_{Ba}$ in Guinea-Pig Gastric Myocytes" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (4): 435~443    
    7. 1998 "ATP-Sensitive $K^+$ Currents in Gastric Myocytes Isolated from Guinea-pig" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (1): 85~93    
    8. 1998 "Characteristics of $Ca^{2+}$ Stores in Rabbit Cerebral Artery Myocytes" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (3): 313~322    
    9. 1998 "Inhibitory Effect of Caffeine on Carbachol-Induced Nonselective Cationic Current in Guinea-Pig Gastric Myocytes" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (3): 353~359    
    10. 1998 "Sensitivity of Rabbit Cerebral Artery to Serotonin is Increased with the Moderate Increase of Extracellular $K^+$" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (6): 695~703    
  • Jun, Jae-Yeoul (31)

  • So, In-Suk (30)

  • 김기환 (51)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
  • 대한약리학회 : 저널
  • 대한생리학회 : 저널
유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기