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Tetrachloroauric Acid Depresses the Activation Processes of Phagocytic Cells

Lee, Chung-Soo   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  );
  • 초록

    Gold compounds depress phagocytic cell responses, including chemotaxis, and respiratory burst. However, the effects of gold compounds on the function of phagocytic cells are variable according to the preparation of medicine. In this study, effect of tetrachloroauric acid on activated neutrophil responses, including respiratory burst, lysosomal enzyme release and change of intracellular $Ca^{2+}$ level and on the synthesis of interleukin-8 and granulocyte-macrophage colony stimulating factor by macrophages was studied. This study further examines how gold compounds affect the activation processes. The respiratory burst stimulated by complement C5a, degraded IgG and PMA in neutrophils was inhibited by tetrachloroauric acid. In contrast to C5a and degraded IgG, PMA-stimulated superoxide production was weakly inhibited by tetrachloroauric acid. Staurosporine, genistein, EGTA and verapamil inhibited superoxide and $H_2O_2$ production caused by C5a and degraded IgG. PMA-stimulated superoxide production was inhibited by staurosporine but was not affected by genistein. Tetrachloroauric acid, genistein, EGTA and verapamil inhibited the release of acid phosphatase and myeloperoxidase, while the effect of staurosporine was not detected. The synthesis of interleukin-8 and granulocyte-macrophage colony stimulating factor by $interleukin-1{\beta}$ in macrophages was inhibited by tetrachloroauric acid. Preincubation with tetrachloroauric acid, genistein, EGTA and verapamil, the elevation of [ $Ca^{2+}_i$ ] evoked by C5a was inhibited. Store-regulated $Ca^{2+}$ entry in thapsigargin-pretreated neutrophils was decreased by the addition of tetrachloroauric acid and genistein. The effect of staurosporine on intracellular $Ca^{2+}$ mobilization was not observed. In conclusion, tetrachloroauric acid may suppress neutrophil responses through its inhibitory action on elevation of intracellular $Ca^{2+}$ level and protein kinase C. It might exhibit an inhibitory effect on the action of protein tyrosine kinase. Tetrachloroauric acid depresses cytokine production by macrophages.


  • 주제어

    Tetrachloroauric acid .   Human neutrophils .   Murine macrophages .   Functional depression.  

 저자의 다른 논문

  • Lee, Chung-Soo (28)

    1. 1990 "활성화된 사람 중성 백혈구에서 ATP와 Adenosine 처리에 따른 생화학적 반응의 변경" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 26 (1): 55~66    
    2. 1991 "$Fe^{2+}$에 의한 지질 과산화에 있어서 Quercetin과 Rutin의 억제 작용" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 27 (1): 69~80    
    3. 1992 "사람 중성호성 백혈구의 기능에 있어서 Arachidonic Acid의 활성화 기전" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 28 (1): 91~102    
    4. 1992 "HOCl과 $NH_2Cl$에 의한 Hyaluronic Acid의 변성에 있어서 Taurine의 억제 효과" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 28 (2): 201~212    
    5. 1993 "Platelet Activating Factor에 의한 대식세포의 활성화에 있어서 칼슘과 Protein Kinase C의 역할" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 29 (1): 107~120    
    6. 1995 "Staurosporine과 Genistein이 C5a 또는 PMA에 의하여 활성화된 호중구에서의 Superoxide와 HOCl 생성에 나타내는 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (1): 115~122    
    7. 1995 "Amitriptyline과 Imipramine이 호중구에서의 Superoxide 생성, Myeloperoxidase 유리, Leukotriene $B_4$생성과 칼슘 동원에 나타내는 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (1): 123~133    
    8. 1995 "Adenosine과 $N^6-cyclopentyladenosine$이 활성화된 중성호성 백혈구에서 Superoxide 생성, 탈과립과 칼슘동원에 나타내는 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (3): 333~344    
    9. 1995 "$Fe^{2+}$$H_2O_2$에 의한 Hyaluronic Acid, Lipid와 Collagen의 산화성 손상에 나타내는 Harmaline과 Harmalol의 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (3): 345~353    
    10. 1995 "Effects of Staurosporine and Genistein on Superoxide Generation and Degranulation in PMA- or C5a-Activated Neutrophils" Journal of biochemistry and molecular biology = 한국생화학회지 28 (3): 210~215    

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