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Effect of Endothelin-1 on Proliferation and Differentiation of Rat Tracheal Epithelial Cells

Kim, Chang-Soo   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Oh, Sae-Ock   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Woo, Jae-Suk   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Jung, Jin-Sup   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Kim, Yong-Keun   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  ); Lee, Sang-Ho   (Department of Physiology, College of Medicine, Pusan National UniversityUU0000613  );
  • 초록

    A number of substances involved in the proliferation and differentiation of the tracheobronchial epithelium have been identified. The defects in the control of the proliferation and differentiation of tracheobronchial epithelial cells appear to constitute crucial steps in the transition of normal cells to neoplastic ones. Endothelin-1 is produced by tracheal epithelial cells, and its receptors are present in tracheal epithelial cells. However, the effect of endothelin-1 on the proliferation and differentiation of tracheal epithelial cells has not been clearly elucidated. This study was undertaken to investigate these actions of endothelin-1 in primary cultured cells of rat tracheal epithelia. Endothelin-1 stimulated proliferation of tracheal epithelial cells 1.5-fold when compared with that of control cells. Endothelin-1 increased mitogen-activated protein kinase (MAPK) activity. Herbimycin A, a tyrosine kinase inhibitor, inhibited endothelin-1-induced proliferation of epithelial cells. The treatment of endothelin-1 during the primary culture of tracheal epithelial cells increased AB-PAS-stained cell population and ciliated cell population 6.5 fold and 1.5 fold, respectively, when compared with those in control cells. The responsiveness to carbachol and forskolin in the $Cl^-$ secretion was increased 1.7 and 1.9 fold, respectively, in the endothelin-treated epithelial cells. These results indicated that endothelin-1 increases proliferation via MAPK pathway and stimulates differentiation to secretory and ciliated cells in rat tracheal epithelial cells.


  • 주제어

    Endothelin-1 .   Rat .   Tracheal epithelial cells .   Proliferation .   Differentiation.  

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  • Oh, Sae-Ok (5)

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    2. 1997 "Cloning of Mouse AQP-CD Gene" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (2): 195~200    
    3. 1998 "cAMP-Dependent Signalling is Involved in Adenosine-Stimulated $Cl^-$ Secretion in Rabbit Colon Mucosa" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (4): 521~527    
    4. 1999 "Activation of SAPK and Increase in Bak Levels during Ceramide and Indomethacin-Induced Apoptosis in HT29 Cells" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 3 (1): 75~82    
    5. 2009 "Involvement of Phospholipase D in Norepinephrine Uptake in PC12 Cells" Journal of experimental & biomedical sciences = 대한의생명과학회지 15 (4): 287~293    
  • Woo, Jae-Suk (29)

  • 정진섭 (27)

  • Kim, Yong-Keun (36)

  • 이상호 (17)

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