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Natural product sciences v.4 no.1, 1998년, pp.26 - 31  

Radioprotective Effect of Lifukang, a Chinese Medicinal Plants Prescription

Kim, Jeong-Hee   (Department of Biochemistry and Institute of Oral Biology, College of Dentistry, KyungHee UniversityUU0001575  ); Kim, Sung-Ho   (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National UniversityUU0001112  ); Lee, Eun-Ju   (Department of Biochemistry and Institute of Oral Biology, College of Dentistry, KyungHee UniversityUU0001575  ); Gao, Jiangshen   (Academy of Traditional Chinese MedicineUU0015258  ); Wu, Zhenyu   (Academy of Traditional Chinese MedicineUU0015258  ); Mar, Woong-Chon   (Natural Products Research Institute, Seoul National UniversityUU0000691  ); Chang, Il-Moo   (Natural Products Research Institute, Seoul National UniversityUU0000691  );
  • 초록

    We have examined in vitro and in vivo radioprotective effect of a Chinese medicinal plants prescription, Lifukang. Micronucleus assay was employed to evaluate in vitro radioprotective effect of Lifukang. In the presence of Lifukang, the frequencies of miconuclei were greatly reduced from 7.2 to 2.9, 1.6 and 1.6% at the concentrations of Lifukang from 0 to 2, 10 and $50{\mu}g/ml$ , respectively. For in vivo assay, we monitored the incidences of apoptotic cells in mouse small intestine crypts and endogeneous spleen colonies. When Lifukang was administered to mice P.O. Or I.P. at doses of 1 mg/ml in drinking water for 7 days or 0.3 mg/mouse 24 hrs prior to irradiations, respectively, the average numbers of apoptotic cells were reduced to 3.1 or 2.3, respectively, as compared to 4.4 acquired from untreated control experiments. In addition, in spleen colony assay, Lifukang increased the number of hematopoietic spleen colonies. When samples were administered after irradiation, better results were obtained. The numbers of spleen colonies were increased from 14 colonies to 18.3 or 19.6 colonies when Lifukang was given through P.O. (1 mg/ml in drinking water for 11 days) or I.P. (0.3 mg/ mouse) after irradiation, respectively.


  • 주제어

    Natural product .   Lifukang .   in vitro and in vivo radioprotective effect.  

 저자의 다른 논문

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    1. 1997 "Pretreatment of Low Dose Radiation Reduces Radiation-Induced Apoptosis in Mouse Lymphoma (EL4) cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (3): 212~217    
    2. 1998 "Reduction of Radiation-induced Chromosome Aberration and Apoptosis by Dithiothreitol" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 21 (6): 683~687    
    3. 1999 "천연 약용식물 추출물의 구강상피세포암 세포주에 대한 항암효과" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 7 (2): 153~157    
    4. 2000 "약용식물 추출물의 산화적 스트레스에 대한 방어효과" 방사선방어학회지 = Journal of radiation protection and research 25 (1): 37~43    
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    6. 2000 "구강암에 대한 약용식물 추출물의 항암효과에 관한 연구" 大韓口腔顎顔面外科學會誌 = Journal of the Korean Association of Oral and Maxillofacial Surgeons 26 (1): 53~58    
    7. 2001 "소목 추출물의 구강암 및 골육종 세포주에 대한 항암작용에 관한 연구" 大韓口腔顎顔面外科學會誌 = Journal of the Korean Association of Oral and Maxillofacial Surgeons 27 (4): 281~288    
  • 김성호 (151)

  • Chang, Il-Moo (52)

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