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생약학회지 v.29 no.4, 1998년, pp.300 - 311   피인용횟수: 1

한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 실험적 고지혈증에 미치는 영향
Effect of Angelicae gigantis Radix Extract on Experimentally Induced Hyperlipemia in Rats

임종훈   (조선대학교 약학대학UU0001180  ); 오형수   (조선대학교 약학대학UU0001180  ); 정명현   (조선대학교 약학대학UU0001180  );
  • 초록

    This study was attempted to investigate the effects of "Angelicae gigantis Radix extract" (AG.EX.) on the activities of GOT and GPT, the contents of total lipid, triglyceride, total cholesterol, phospholipid and ${\beta}-lipoprotein$ in serum, and the weight change ratio of body, liver and spleen in the experimentally induced hyperlipemic rats by administering the extract of 300 and 500 mg/kg p.o.. Significant test was performed by comparision with the biochemical values between control group and experimentally hyperlipemic rats. In the activities of s-GOT and s-GPT inhibition effects were significantly appeared in all dose of AG.EX. (especially more excellent in ethanol extract) and Angelicae acutilobae Radix extract (AA.EX.) as compared with the control group. The content of total lipid was remarkably decreased in all sample group when compared with the control group, and AA.EX. showed more excellent decreasing effect than AG.EX. The contents of triglyceride and total cholesterol were significantly lowered in all sample group, and more significantly decreased in water extract of AG.EX. and ethanol extract of AA.EX. The content of phospholipid was significantly decreased in all sample group and AG.EX. was more significantly decreased than AA.EX. The increasing rate of body weight in all sample groups except AA.EX. 500 mg/kg was increased more than control group and more significantly remarkable in dose of 300 mg/kg than 500 mg/kg. The increasing rate of liver weight in all sample groups was increased more than control group, and AG.EX. was more increased than AA.EX.


  • 주제어

    Angelicae gigantis Radix .   Angelicae acutilobe Radix .   GOT .   GPT .   antihyperlipemic activity .   body .   liver .   spleen weight.  

  • 이 논문을 인용한 문헌 (1)

    1. Chang, Sang-Keun ; Kim, Jun-Ho ; Oh, Hae-Sook 2008. "The Development of Functional Cold Buckwheat Noodles Using Biological Activities of Hot Water Extracts of Ligularia fischeri and Angelica gigas Nakai" 韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, 23(4): 479~488     

 저자의 다른 논문

  • 임종훈 (1)

    1. 1998 "한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 약물성 간장해에 대한 보호 효과" 생약학회지 29 (4): 402~412    
  • 오형수 (1)

  • Chung, Myung-Hyun (20)

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