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생약학회지 v.29 no.4, 1998년, pp.402 - 412   피인용횟수: 1

한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 약물성 간장해에 대한 보호 효과
Protective Effects of Angelicae gigantis Radix Extract on Hepatic Injury Induced by Toxic Drugs in Rats

오형수   (조선대학교 약학대학UU0001180  ); 임종훈   (조선대학교 약학대학UU0001180  ); 정명현   (조선대학교 약학대학UU0001180  );
  • 초록

    This study was attempted to investigate the effect of 'Angelicae gigantis Radix extract (AG.EX.)' and 'Angelicae acutilobae Radix extract (AA.EX.)' on the activities of GOT, GPT and alkaline phosphatase (A1.P), the contents of total cholesterol in serum of $CCl_4$ and D-galactosamine intoxicated rats, and the weight change ratio of body, liver and spleen in $CCl_4-intoxicated-rats$ by administering the extract of 300 and 500 mg/kg P.O.. Significant test was performed by comparision with the biochemical values between intoxicated-control group and extract-administered group. The activities of s-GOT, s-GPT and the contents of total cholesterol elevated by $CCl_4-intoxication$ were significantly decreased in all dose (300, 500 mg/kg) of Angelicae gigantis Radix-water extract (AG.WEX.) and alcohol extract (AG.AEX), and Angelica acutilobae Radix-water extract (AA.WEX.) and alcohol extract (AA.AEX.), respectively, as compared with the control group. And administered group of 300 mg/kg showed more significant decreasing effect than 500 mg/kg, and more significantly decreased in water extract of AG.EX. and ethanol extract of AA.EX. But in the activities of s-A1.P. inhibition effect were significantly decreased only in a dose of 300 mg/kg of AA.WEX. and AA.AEX. The activities of s-GOT and s-GPT elevated by D-galactosamine were not decreased in all samples, as compared to intoxicated-control group. But the activities of s-Al.p was significantly decreased as compared with control groups, in all samples and administration of 300 mg/kg was more significantly decreased than 500 mg/kg. The contents of total cholesterol remarkably decreased than the normal groups by D-galactosamine intoxication was not recovered in all samples. The increasing rate of the body weight increased by $CCl_4-intoxication$ were not decreased than the $CCl_4-control$ group in all sample groups. The increasing rate of liver weight increased by $CCl_4-intoxication$ were significantly decreased in 300 mg/kg of AA.AEX.AG.WEX. and AA.WEX., respectively, as compared with $CCl_4-control$ group.


  • 주제어

    Angelicae gigantis Radix .   Angelicae acutilobae Radix .   GOT .   GPT .   alkaline phosphatase .   total cholesterol .   liver protective activity .   $CCl_4$ .   D-galactosamine-intoxicated rats.  

  • 이 논문을 인용한 문헌 (1)

    1. Kang, Shin-Jyung ; Kim, Ae-Jung ; Lee, Myoung-Sook ; Lee, Yeon-Hee ; Ji, Joong-Ku 2011. "The effect of enhancing eye-wrinkle applying traditional herb medicine cosmetics" 한국산학기술학회논문지 = Journal of the Korea Academia-Industrial cooperation Society, 12(1): 335~340     

 저자의 다른 논문

  • 오형수 (1)

    1. 1998 "한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 실험적 고지혈증에 미치는 영향" 생약학회지 29 (4): 300~311    
  • 임종훈 (1)

  • Chung, Myung-Hyun (20)

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