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The plant pathology journal v.18 no.1, 2002년, pp.18 - 22  

Antiviral, Antimicrobial, and Cytotoxic Properties of Peptavirins A and B Produced by Apiocrea sp.14T

Kim, Young-Ho   (School of Agricultural Biotechnology and research Center for New Bio-Materials in Agriculture, Seoul National UniversityUU0000691  ); Yeo, Woon-Hyung   (Korea ginseng and Tobacco Research Institute  ); Yun, Bong-Sik   (Korea Research Institute of Bioscience and BiotechnologyCC0186997  ); Kim, Young-Sook   (Korea Research Institute of Bioscience and BiotechnologyCC0186997  ); Lee, Sang-Jun   (Korea Research Institute of Bioscience and BiotechnologyCC0186997  ); Yoo, Ik-Dong   (Korea Research Institute of Bioscience and BiotechnologyCC0186997  ); Kim, Kab-Sig   (Korea ginseng and Tobacco Research Institute  ); Park, Eun-Kyung   (Korea ginseng and Tobacco Research Institute  ); Lee, Jong-Chull   (Korea ginseng and Tobacco Research Institute  );
  • 초록

    Two peptaibol antibiotics, peptavirins A and B, which exhibited strong inhibitory effect against Tobacco mosaic vials (TMV) infection, were isolated from steam-cooked rice culture of Apiocrea sp.14T. The peptavirins were identified as new derivatives of chrysospermins, which are 19-mer and have been reported to be produced in a fungal isolate. The physicochemical properties of the peptavirins were mostly identical with chrysospermins A through D except for the UV absorption spectrum. The peptavirins inhibited the growths of the Grampositive bacteria tested, including the plant pathogenic bacterium, Corynebacterium lilium, and the fungus, Aspergillus niger. Peptavirin A was somewhat cytotoxic to cancer cell lines, especially K562 (leukemia) and UACC 62 (melanoma), whereas peptavirin B only exhibited slight cytotoxicity.


  • 주제어

    antimicrobial activity .   Apiocrea sp.   .   cytotoxicity .   peptavirins .   peptaibol antibiotics.  

  • 참고문헌 (25)

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