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韓國營養學會誌 = The Korean journal of nutrition. v.35 no.4, 2002년, pp.414 - 420   피인용횟수: 10

동충하초 (Cordyceps Militaris)가 고지방식이를 섭취한 흰쥐의 지질대사, 단백질농도 및 효소활성에 미치는 영향
The Effects of Cordyceps Militaris on Lipid Metabolism, Protein Levels and Enzyme Activities in Rats Fed a High Fat Diet

고진복   (신라대학교 생명과학과UU0000867  );
  • 초록

    동충하초 (Cordyceps militaris)의 자실체와 균사체가 고지방 식이를 섭취한 성숙된 흰쥐의 영양 생리활성에 미치는 영향을 평가하고자, 생후 35주령의 흰쥐에 표준식이를 급여한 정상군, 표준식이에 15% 돈지를 첨가한 식이를 급여한 고지방군, 고지방 식이에 자실체 및 균사체를 각각 3%씩 첨가한 식이를 급여한 군 등 4군으로 나누어 5주간 사육하였다. 실험동물의 체중증가, 간의 무게 및 식이효율은 고지방군에 비하여 자실체군 및 균사체군이 유의하게 감소되어 정상군과 비슷한 수준으로 체중과 간의 무게를 정상으로 유지시켜 주는 효과가 나타났다. 식이섭취량은 고지방군과 동충하초군들이 비슷한 수준을 유지하였다. 신장, 췌장 및 심장의 무게는 정상군과 각 실험군이 비슷하였다. 간의 총 지질과 콜레스테롤 농도 및 간과 혈청의 중성지질 농도는 고지방군에 비하여 자실체군 및 균사체군이 유의하게 감소되었다. 혈청의 총 콜레스테롤 및 인지질 농도는 정상군에 비하여 각 실험군이 유의하게 증가되었다. 혈청의 HDL-콜레스테롤 농도는 정상군에 비하여 자실체군 및 균사체군이 유의하게 증가되었다. 고지방군에 비하여 자실체군의 총 콜레스테롤에 대한 HDL-콜레스테롤 비율은 유의하게 증가되었고, 동맥경화지수는 감소되었다. 혈청의 총 단백질 농도는 정상군에 비하여 고지방군 및 균사체군이 유의하게 증가되었다. 혈청의 알부민, 혈당 및 혈색소 농도는 정상군과 각 실험군이 비슷하여 정상 수준을 유지하였다. 혈청의 glutamic pyruvic transaminase, glutamic oxaloacetic transaminase 및 ${\gamma}$ -glutamyltr-anspeptidase의 활성은 정상군과 각 실험군이 유사한 경향을 보였다. Lactic dehydrogenase 활성은 고지방군에 비하여 자실체군 및 균사체군은 유의하게 증가되어 정상군과 비슷하였다. Alkaline phosphatase 활성은 정상군에 비하여 각 실험군이 유의하게 감소되었다. 이상의 결과로 보아 고지방 식이에 3%동충하초의 자실체와 균사체 섭취에 의한 체중과 간의 무게가 정상수준을 유지하였고, 간의 총 지질과 콜레스테롤 농도 및 간과 혈청의 중성지질 농도를 낮추는 효과가 있는 것으로 나타났다.


    The effects of Cordyceps militaris on weight gain, flood intakes, flood efficiency ratios, serum and hepatic lipid concentrations, serum protein levels and serum enzyme activities, were studied in adult male rats. Sprague-Dawley rats, 35 weeks old, were given four different types of diets for a succeeding period of five weeks: either a normal diet(5% com oil), a high fat diet(5% com oil + 15% lard). a CF diet (high fat diet + 3% Suiting body of cordyceps militaris), or a CM diet (high fat diet + 3% mycelium of cordyceps military). The body weight gains, hepatic weights and food efficiency ratios of the rats find (high fat) diets with CF and CM were significantly decreased compared with those find the high fat diet, but were similar to those find the normal diet. The concentrations of serum and hepatic triglycerides, and hepatic total lipids and cholesterol, of rats given CF or CM diets were significantly lower than those given the high fat diet. But the concentrations of total cholesterol, HDL-cholesterol, phopholipid and total protein in the serum of rats find the high fat, CF or CM diets were significantly higher than those find the normal diet. In the serum of the rats find the CF diet, the HDL-cholesterol/total cholesterol ratio was significantly higher but the atherogenic index was significantly lower than those fed the high fat diet. The alkaline phosphatase activity in the serum of the rats find the high fat, CF, and CM diets was more significantly decreased compared to rats on the normal dirt. No differences were noted in the weights of the pancreas, kidney and heart, the serum concentrations of glucose, hemoglobin and albumin, and the activities of GOT, GPT and ${\gamma}$ -GTP, among the rats on all the experimental diets. In conclusion, the rats find the Cf or CM diets maintained normal body and hepatic weights. Despite of the high intake of fats in the CF and CM diets, the concentrations of total lipids, cholesterol and triglycerides were decreased in the liver, also, the concentration of triglycerides was decreased in the serum.


  • 주제어

    Cordyceps militaris .   lard .   cholesterol .   triglyceride .   protein .   enzyme activities.  

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    7. Jin, Yong-Xie ; Yoo, Youn-Sook ; Han, Eun-Kyung ; Kang, Il-Jun ; Chung, Cha-Kwon 2008. "Artemisia capillaris and Paecilomyces japonica Stimulate Lipid Metabolism and Reduce Hepatotoxicity Induced by Carbon Tetrachloride in Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 37(5): 548~554     
    8. Kim, Ki-Chul ; Kim, Hae-Ja ; Cho, Hwa-Eun ; Choi, Yun-Hee ; Lee, Ki-Nam ; Chong, Myong-Soo 2009. "Effect of Blood Glucose Levels and Lipid Metabolism on Streptozotocin-induced Diabetic Rats of Processed Sulfur with Cordyceps Militaris Mycelium" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 23(1): 144~149     
    9. Han, Eun-Kyung ; Jin, Yong-Xie ; Yoo, Yoon-Sook ; Jung, Eui-Jin ; Lee, Ji-Young ; Chung, Cha-Kwon 2009. "Effect of Artemisia capillaris and Paecilomyces japonica on the Reduction of Hepatotoxicity and Lipid Metabolism Induced by Ethanol" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(8): 1016~1023     
    10. Nam, Byung-Hyouk ; Jo, Wool-Soon ; Choi, Yoo-Jin ; Lee, Jae-Yun ; Kang, Eun-Young ; Jeong, Min-Ho ; Lee, Jae-Dong 2010. "Inhibitory Effects of Melanin Secretion on B16 Melanoma cell of Cordyceps militaris Water Extract" 한국균학회지 = The Korean journal of mycology, 38(2): 167~171     

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