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國內 飼育 원숭이의 心電圖에 관한 硏究
Studies on the Electrocadiogram in Non-human Primates Reared in Korea

서진석   (충남대학교 수의과대학UU0001302  ); 서지민   (충남대학교 수의과대학UU0001302  ); 이버들   (충남대학교 수의과대학UU0001302  ); 송근호   (충남대학교 수의과대학UU0001302  ); 이수진   (충남대학교 수의과대학UU0001302  ); 김덕환   (충남대학교 수의과대학UU0001302  ); 현병화   (생명공학연구소CC0187855  ); 신남식   (에버랜드  );
  • 초록

    Non-human primates are widely used for experimental animal and raised as companion animal in Korea. To establish the electrocadiogram (ECG) of non-human primates that are domestically raised, the author measured bipolar limb leads and augmented unipolar limb leads, after tiletamine/zolazepam (TZ) injection as sedative agents. The amplitudes of P,Q, R,S and T wave and duration time of P wave, QRS complex, PR and QT interval in each lead of ECG were evaluated in 7 non-human primates at 15 minutes after TZ injection, respectively. The amplitude of P wave in I, II,III, aVR, aVL and aVF leads revealed 0.06 $\pm$ 0.05,0.14 $\pm$ 0.05, 0.1 $\pm$ 0.05,-0.11 $\pm$ 0.06,-0.04 $\pm$ 0.04 and 0.12 $\pm$ 0.05 mV respectively. The amplitude of Q wave revealed -0.16 $\pm$ 0.15, -0.23 $\pm$ 0.18, -0.17 $\pm$ 0.13, 0.16 $\pm$ 0.13, 0.04 $\pm$ 0.09 and -0.2 $\pm$ 0.13 mV, respectively. The amplitude of R wave revealed 0.56 $\pm$ 0.56, 1.24 $\pm$ 0.67, 0.92 $\pm$ 0.33, -0.37 $\pm$ 1.14, -0.22 $\pm$ 0.47 and 1.12 $\pm$ 0.47 mV, respectively. The amplitude of S wave revealed -0.02 $\pm$ 0.08, -0.04 $\pm$ 0.06, -0.06 $\pm$ 0.04, 0.02 $\pm$ 0.04, 0.04 $\pm$ 0.09 and -0.04 $\pm$ 0.06 mV, respectively. The amplitude of T wave revealed -0.01 $\pm$ 0.15,-0.02 $\pm$ 0.13, 0.01 $\pm$ 0.08, 0.02 $\pm$ 0.12, 0.01 $\pm$ 0.11 and -0.03 $\pm$ 0.09 mV, respectively. The duration time of P wave revealed 0.05 $\pm$ 0.01, 0.04 $\pm$ 0.01, 0.05 $\pm$ 0.02, 0.05 $\pm$ 0.02, 0.04 $\pm$ 0.01 and 0.04 $\pm$ 0.01 sec, respectively. The duration time of QRS complex revealed 0.05 $\pm$ 0.02,0.05 $\pm$ 0.01, 0.05 $\pm$ 0.01, 0.04 $\pm$ 0.01, 0.05 $\pm$ 0.01 and 0.05 $\pm$ 0.01 sec, respectively. The duration time of PR interval revealed 0.08 $\pm$ 0.01, 0.07 $\pm$ 0.01,0.08 $\pm$ 0.03, 0.08 $\pm$ 0.01, 0.08 $\pm$ 0.01 and 0.08 $\pm$ 0.01 sec, respectively. The duration time of QT interval revealed 0.23 $\pm$ 0.06, 0.22 $\pm$ 0.05, 0.23 $\pm$ 0.06, 0.23 $\pm$ 0.06, 0.24 $\pm$ 0.05 and 0.22 $\pm$ 0.02 sec, respectively. No significant changes were observed in e amplitude of P and T waves. The amplitude of QRS complex in ketamine group was higher than that of TZ group. However, no significant changes were observed in both intra-group and inter-group. There were no significant changes in the duration time of P wave, QRS complex and PR interval obtained from both groups. Also, the duration time of QT interval in TZ group was significantly longer at 30 min.(P


  • 주제어

    electrocadiogram .   non-human primates .   tiletamine/zolazepam .   ketamine.  

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