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개에서 Propofol 점적투여율 변화가 심혈관계에 미치는 영향
Cardiovascular Effects of Propofol Infused for Maintenance of Anesthesia in Dogs

권영삼   (경북대학교 수의과대학UU0000096  ); 장광호   (경북대학교 수의과대학UU0000096  ); 장환수   (경북대학교 수의과대학UU0000096  ); 박현정   (경북대학교 수의과대학UU0000096  ); 임재현   (경북대학교 수의과대학UU0000096  ); 오태호   (경북대학교 수의과대학UU0000096  ); 엄기동   (경북대학교 수의과대학UU0000096  ); 장인호   (경북대학교 수의과대학UU0000096  );
  • 초록

    Cardiovascular effects of propofol, were assessed after premedication with xylazine(1.0 mUkg, IM) under oxygen supply(200 ml/kg/min) via a endotracheal tube. Twelve adult mixed-breed dogs were divided into four groups; 0.2(Group 1), 0.4(Group 2), 0.6(Group 3) and 0.8 mg/kg/min(Group 4) of propofol respectively. Arterial blood pressure and electrocardiogram were monitored with a physiograph after an arterial catheter was inserted into the femoral artery. pH, arterial carbon dioxide tension( $PaCO_2$ and arterial oxygen tension( $PaO_2$ ) were evaluated with arterial blood collected through the inserted catheter. Diastolic arterial pressure, systolic arterial pressure and mean arterial pressure were decreased slightly in Group I IIand III, but decreased significantly in Group IV. They were increased rapidly after stopping propofol infusion in Group IV pH was maintained in normal range in Group I, II and m, but was decreased in proportion to time passing in Group IV. $PaCO_2$ was increased significantly only in Group IV but $PaO_2$ was maintained in normal range in all groups Although heart rate was recorded in normal range for 90 minutes, arythmia was noted after stopping propofol infusion in all groups. It was concluded that propofol depressed the cardiovascular system in proportion to infusion dosage, and 0.8 mg/kg/min of propofol infusion rate was not appropriated in canine anesthesia with xylazine premedication.


  • 주제어

    xylazine .   propofol .   infusion rate .   anesthesia .   dog.  

  • 참고문헌 (23)

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    18. Adverse effects of administration of propofol with various preanesthetic regimens in dogs , Smith JA;Gaynor JS.Bednarski RM;Muir WW , JAVMA / v.202,pp.1111-1115,
    19. Cardiovasculat effects of a continuous two-hour propofol infusion in dogs comparison with isoflurane anesthesia , Keegan RD;Greene SA , Vet Surg / v.22,pp.537-543,
    20. Propofol - A review of its pharmacokinetic properties and use as an intravenous anesthetic , Langley MS;Heel RC , Drugs / v.35,pp.334-372,
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    22. Effect of graded infusion rates of propofol an regional and global left ventricular function in the dog , Puttick RM;Diedericks J;Sear JW;Glen JB;Foex P;Ryder WA , Br J Anaesth / v.69,pp.375-381,
    23. Cardiopulminary effects of propofol infusion in llamas , Duke T;Egger CM;ferguson JG;Frketic MM , Am J Vet Res / v.58,pp.153-156,

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