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韓國營養學會誌 = The Korean journal of nutrition. v.35 no.6, 2002년, pp.635 - 642   피인용횟수: 4

Isoflavone 섭취가 흰쥐의 지방대사 및 면역능력에 미치는 영향
The Effects of Isoflavone on Lipid Metabolism and Immune Responses in SD Rats

정미경   (단국대학교 식품영양학과UU0000336  ); 방명희   (단국대학교 식품영양학과UU0000336  ); 설소미   (단국대학교 식품영양학과UU0000336  ); 김우경   (단국대학교 식품영양학과UU0000336  );
  • 초록

    This study was performed to investigate the effects of isoflavone consumption on plasma and liver lipid profiles and immune responses in Sprague-Dawley male rats. Experimental animals fed isoflavone at various doses for 4 weeks (0, 1095, 2190, 4380 isoflavone mg/kg diet). Exposure to isoflavone decreased the food consumption and final body weights of rats without decreasing the relative weights of organs, hemoglobin and hematocrit. And the plasma cholesterol and LDL-cholesterol, liver total lipid, cholesterol and triglyceride concentrations were significantly decreased by isoflavone intakes. The absolute and relative weights of thymus were significantly decreased in groups fed isoflavone than in control. Also splenocyte proliferations with Con A or PHA were decreased according to isoflavone consumption in rats, although there was not significant. These results demonstrate that isoflavone intakes significantly improve lipid profiles in plasma and liver. But the effects of isoflavone intakes on immune responses are needed further experiments.


  • 주제어

    isoflavone .   lipid metabolism .   immune response.  

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  • 이 논문을 인용한 문헌 (4)

    1. 2003. "The Effect of Isoflavone and/or Grape Seed Oil Supplementation on Blood Lipid Profiles and Bone Strength in Ovariectomized Female Rats" 韓國營養學會誌 = The Korean journal of nutrition., 36(7): 667~674     
    2. Lee Okhee 2004. "Effects of Supplementation of Puerariae Radix Ethanol Extract on the Antioxidative Defense System in Rats" 韓國營養學會誌 = The Korean journal of nutrition., 37(10): 872~880     
    3. Lee, Seon-Hye ; Kim, Mi-Hyun ; Park, Mi-Na ; Lee, Yeon-Sook 2007. "Effects of Genistein Supplementation on Fatty Liver and Lipid Metabolism in Rats Fed High Fat Diet" 韓國營養學會誌 = The Korean journal of nutrition., 40(8): 693~700     
    4. Cho, Hye-Yeon ; Yang, Jeong-Lye ; Noh, Kyung-Hee ; Kim, Jin-Ju ; Kim, Young-Hwa ; Huh, Kyung-Hye ; Song, Young-Sun 2007. "Anti-atherogenic Effect of Isoflavone through Hypolipidemic, Anti-oxidative and Anti-inflammatory Actions in C57BL/6 Mice" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 36(3): 276~283     

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