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韓國營養學會誌 = The Korean journal of nutrition. v.35 no.8, 2002년, pp.840 - 847   피인용횟수: 3

고지방식을 섭취한 본태성 고혈압쥐에서 칼슘과 소디움 섭취가 혈압과 무기질 대사에 미치는 영향
Effect of Dietary Ca and Na Levels on Blood Pressure and Mineral Metabolism in Spontaneously Hypertensive Rats Fed High Fat Diet

이연숙   (서울대학교 식품영양학과UU0000691  ); 김은미   (김포대학 호텔조리과UU0000317  );
  • 초록

    This study explored the effect of dietary levels of Na and Ca on spontaneously hypertensive rats (SHR). SHR were randomly divided into 5 groups and fed a high fat/cholesterol diet containing three levels of Na (0.05, 0.1, 1.5%) and Ca (0.1, 0.5, 1.5%) for 9 weeks. Body weight gain was not influenced by dietary intake but water intake significantly increased in high Na supplementation. Systolic blood pressure was not influenced by dietary Na and Ca levels but was decreased by dietary low Na/high Ca levels at 9 weeks. Angiotensin-II level was affected by dietary Na level but not by Ca levels. Plasma Ca, Mg, K and Na levels were in the normal range regardless of dietary Na and Ca levels. Weight, and K and Na contents of the heart and kidney were not significantly different among those with different dietary Na and Ca levels. Ca and Mg contents of the heart and kidney were significantly higher in the normal Na/normal Ca group. Ca and Mg in the feces were higher in those with high Ca intake. Na in the feces was higher in those with high Na intake. Therefore, Na and Ca had different mechanisms in the hypertension/hyperlipidemia models, respectively. And we suggested that Mg must be supplemented when Ca intake was high because Mg excretion was increased by Ca supplementation.


  • 주제어

    spontaneously hypertensive rat (SHR) .   hyperlipidemic .   calcium .   sodium .   blood pressure.  

  • 참고문헌 (35)

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  • 이 논문을 인용한 문헌 (3)

    1. Jo, Jin-Ho ; Kim, Byung-Gi ; Han, Chan-Kyu ; Jung, Eun-Bong ; Cho, Seung-Mock 2008. "Effects of Milk with Boiled-Dried Large Anchovy, Calcium-Fortifying Materials and Fortified-Calcium Milk on Calcium Absorption Rate and Bone Metabolism in Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 37(4): 459~464     
    2. Cho, Yoon-Hee ; Oh, Se-Jong 2010. "Casein Phosphopeptide (CPP)-Producing Activity and Proteolytic Ability by Some Lactic Acid Bacteria" Korean journal for food science of animal resources = 한국축산식품학회지, 30(3): 443~448     
    3. 2013. "" Korean journal for food science of animal resources = 한국축산식품학회지, 33(3): 369~376     

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