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Hematological Aspects in A Endotoxemic Young Rabbit Model

Park, Seok-Cheol   (Department of Clinical Laboratory Science, College of Health Science, Catholic University of PusanUU0013933  ); Kwon, Heun-Young   (Department of Clinical Laboratory Science, College of Health Science, Catholic University of PusanUU0013933  ); Kim, Jai-Young   (Department of Clinical Laboratory Science, College of Health Science, Catholic University of PusanUU0013933  ); Hwang, Soo-Myung   (Department of Clinical Laboratory Science, College of Health Science, Catholic University of PusanUU0013933  ); Kim, Tae-Un   (Department of Clinical Laboratory Science, College of Health Science, Catholic University of PusanUU0013933  ); Seong, Hee-Kyung   (Department of Medical Laboratory Science, InJe UniversityUU0001067  ); Kim, Yang-Weon   (Department of Emergency Medicine, Pusan Paik Hospital, College of Medicine, Inje UniversityUU0001067  ); Lee, Won-Jae   (Department of Microbiology, Pukyong National UniversityUU0000598  );
  • 초록

    Gram-negative septicemia, which continues to be a serious clinical problem, is one of the major causes of morbidity and mortality in hospitalized patients. Endotoxin of gram-negative bacteria is a pivotal pathogen of sepsis. To understand the effect of endotoxin on hematological aspect and the time course in early childhood, this study was designed with experimental septic model of young rabbits (8 week-old). Rabbits were divided into control (n=7) and endotoxin group (0.50 mg/kg of endotoxin). The endotoxin group was subdivided into six groups by the sampling times: 3, 6, 12, 24, 48 and 72 hr-group (E-G $_{3}$ , E-G $_{6}$ , E-G $_{12}$ , E-G $_{24}$ , E-G $_{48}$ and E-G $_{72hrs}$ , each n=7). The evaluation of CBC, activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen concentration, coagulation factors and D-dimer were taken from the bloods. The number of leukocytes was lower in E-G $_{3}$ and E-G $_{6hrs}$ (due to pantocytopenia), whereas it was higher in E-G $_{24}$ and E-G $_{48}$ (due to neutrophilia and/or lymphophilia) than in control group (P $_{3}$ , E-G $_{6}$ , E-G $_{12}$ , E-G $_{24}$ and E-G $_{48hrs}$ were lower than those of control group (P $_{3}$ , E-G $_{6}$ , E-G $_{12}$ , E-G $_{24}$ and E-G $_{48hrs}$ were higher than those of control group (p $_{3}$ , E-G $_{6}$ , E-G $_{12}$ , E-G $_{24}$ and E-G $_{72hrs}$ were longer while PT in E-G $_{3}$ , E-G $_{6}$ , E-G $_{48}$ and E-G $_{72hrs}$ were higher than those of control group (p $_{3}$ , E-G $_{6}$ and E-G $_{12}$ but higher in E-G $_{48}$ and E-G $_{72hrs}$ than those of control (p $_{3}$ , E-G $_{6}$ , E-G $_{12}$ and E-G $_{24hrs}$ whereas they were higher in E-G $_{48}$ and E-G $_{72hrs}$ than in control group (p $_{48}$ and E-G $_{72hrs}$ were higher than those of control group (P


  • 주제어

    Endotoxin .   Rabbit .   Hematology.  

 저자의 다른 논문

  • Kim Jai-Young (2)

    1. 2004 "Cerebral Blood Flow Velocity of Young People in Their Twenties" Journal of experimental & biomedical sciences = 대한의생명과학회지 10 (4): 467~472    
    2. 2005 "Influences of an Experimental Exposure to Excavator Noise on the Cardiac Factors and Cerebral Hemodynamics" Journal of experimental & biomedical sciences = 대한의생명과학회지 11 (3): 397~405    
  • Hwang, Soo-Myung (13)

  • Kim, Tae-Un (8)

  • 김양원 (11)

  • 이원재 (18)

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