본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Effects of Temperature on the Pharmacokinetics of Ciprofloxacin in the Cultured Black Rockfish (Sebastes schlegeli) and Olive Flounders (Paralichthys olivaceus)

Kim Jin Woo    (Pathology Division, National Fisheries R&D Institute   ); Jo Mira    (Pathology Division, National Fisheries R&D Institute   ); Jung Sung Hee    (Pathology Division, National Fisheries R&D Institute   ); Jee Bo Young    (Pathology Division, National Fisheries R&D Institute   ); Choi Dong Lim    (Pathology Division, National Fisheries R&D Institute   ); Jo QTae    (Aquaculture Division, National Fisheries R&D Institute  );
  • 초록

    Temperature-dependent pharmacokinetics of ciprofloxacin (CIP) was studied in the cultured olive flounders, Paralichthys olivaceus, and black rockfish, Sebastes schlegeli using high performance liquid chromatography (HPLC) originally developed for quinolone determination from livestock. Pharmacokinetics of CIP was apparently affected by ambient water temperature. In a two-compartment model for flounders after oral dosage of 20 mg/kg, $K_{01},\;at\;13^{\circ}C$ and $23^{\circ}C$ were 4.18 and 1.20/hr, respectively. The $K_{10},\;T_{max}\;and\;C_{max}\;at\;13^{\circ}C$ were 5.574/hr, l4.37 ${\mu}g/mL\;and\;3.15{\mu}g/mL,$ respectively. The corresponding values at $23^{\circ}C$ were l2.84/hr, 15.39 ${\mu}g/mL\;and\;6.38{\mu}g/mL$ , respectively. The AUC, $T_{1/2} (\alpha)\;and\;T_{1/2}\;(\beta)$ were 278.23 ${\mu}g \cdot hr/mL$ , 0.24hr and 47.02hr at $13^{\circ}C$ and 3l7.8l ${\mu}g \cdot hr/mL$ , 0.30 hrs and 60.78hrs at $23^{\circ}C$ for the flounder, respectively. Similar CIP pharmacokinetics were revealed in the black rockfish after oral dosage of 20 mg/kg under the two water temperature regimes. These pharmacokinetical results have some implication in the optimal usage of recently introduced antibacterials in the farmed fish, which were primarily adapted for poultry and mammalian species.


  • 주제어

    Ciprofloxacin .   Pharmacokinetics .   Temperature .   HPLC .   Olive flounder .   Black rockfish.  

  • 참고문헌 (23)

    1. Bakhouya, A., M. Saidna and J.M. Vergnaud. 1996. Calculation of the antibiotic level in the plasma with an oral erosin-controlled dosage form. Int. J. Pharm., 143, 143-149 
    2. Belal, F., A.A. Majed and A.M. Al-Obaid. 1999. Methods of analysis of 4-quinolone antibacterials. Talanta, 50, 765-786 
    3. Bergan, T., S.B. Thorsteinsson and R. Solberg. 1987. Pharmacokinetics of ciprofloxacin: intravenous and increasing oral doses. Am. J. Med., 82, 97-102 
    4. Cester, C.C. and P.L. Toutain. 1997. A compregensive model for enrofloxacin to ciprofloxacin transformation and disposition in dog. J. Pharmaceut. Sci., 86, 1148-1155 
    5. Dupont, H.L., C.D. Ericsson and A. Robinsson. 1987. Current problems in antimicrobial therapy for bacterial enteric infection. Am. J. Med., 82, 324-328 
    6. Garcia Ovando, H., N. Gorla, C. Luders, G. Poloni, C. Errecalde, G. Preto and I. Puelles. 1999. Comparative pharmacodinetics of enrofloxacin and ciprofloxan in chickens. J. Vet. Pharm., 22, 209-212 
    7. Grave, K., A. Markestad and M. Banggen. 1996. Comparison in prescribing patterns of antibacterial drugs in salmonid farming in Norway during the periods 1980-1988 and 1989-1994. J. Vet. Pharmacol.. Ther., 19, 184-191 
    8. Herman, R.L., D. Collis and L.D. Bullock. 1969. Oxytetracycline residues in different tissues of trout. Technical Papers of the bureau of Sport Fisheries and Wildlife, No. 37 
    9. Hooper, D.C. and J.S. Wolfson. 1993. Winnolone antimicrobial agents. 2nd ed. edited by David, C. & John, S., Washington D.C. 
    10. Intorre, L., G. Mengozzi, S. Bertini, M. Bagliacca, E. Luchetti and G. Soldani. 1997. The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the Muscovy duck. Vet. Res. Commun., 21, 127-136 
    11. Jacobsen, M.D. 1989. Withdrawal times of freshwater rainbow trout, Salmo gairdneri Richardson, after treatment with oxolinic acid, oxytetracycline and trimethoprim. J. Fish Diseases, 12, 29-36 
    12. Kasuga, Y., A. Sugitani, F. Yamada, M. Arain and S. Moridawa. 1984. Oxolinic acid residues in tissues of cultured rainbow trout and ayu fish. J. Food Hyg. Soc. Jpn., 25, 512-615 
    13. Kenneth, N. Kreuzer. 1998. Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors. Biochimica et Biophysica Acta, 1400, 339-347 
    14. Kim, M.S., S.W. Park, M.D. Huh and H.D. Jeong. 1998. Effect of temperature and bacterial infection on the absorption and elimination of oxolinic acid in Nile tilapia (Oreochromis niloticus). J. Korean Fish. Soc., 31, 677-684 (in Korean) 
    15. Lesse, A.J., C. Freer and R.A. Salata. 1987. Oral ciprofloxacin therapy for gram-negative bacillary osteomyelitis. Am. J. Med., 82, 247-253 
    16. McCracken, A., S. Fidgeon, JJ. O'Brien and D. Anderson. 1976. An investigation of antibiotic and drug residues in fish. J. Appl. Bacteriol., 40, 61-66 
    17. Newson, S.W.B., P. Murphy and J. Matthews. 1986. A comparative study of ciprofloxacin and trimethoprim in the treatment of urinary infections in geriatric patients. J. Antimicrob. Chemother., 18, 111-115 
    18. Posyniak, A., J. Zmudzki and S. Semeniuk. 2001. Effects of the matrix and sample preparation on the determination of fluoroquinolone residues in animal tissue. J. Chromatogr. A, 914, 89-94 
    19. Samuelsen, O.B. and A. Ervik. 1999. A single dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in Atlantic halibut, Hippoglossus hippoglossus L., held in sea water at 9$^\circ C$. J. Fish Diseases, 22, 13-23 
    20. Takemura, M. and I. Hayakawa. 2001. Recent advances in the field of quinolones. II Farmaco, 56, 37-40 
    21. Vance, B.K., K.R. Guay and J.C. Rotschafer. 1990. Clinical pharmacokinetices of ciprofloxacin. Clin. Pharmacokinect, 19, 434-461 
    22. Uno, K., T. Aoki and R. Ueno. 1993. Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Onchorhynchus mykiss). Aquaculture, 115, 209-219 
    23. Yorke, J.C. and P. Froc. 2000. Quantitation of nine quinolones in chicken tissues by high-performance liquid chromatography with fluorescence detection, J. Chromatogr. A, 882, 63-77 

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기