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Nutraceuticals and food v.8 no.1, 2003년, pp.7 - 12  

Immunosuppressive Effect of the Intraperitonially Injected Pine Needle Distillate in Mice

Chung, Young-Jin   (Department of Food and Nutritional  ); Bae, Myung-Won   (Department of Food and Nutritional  ); Chung, Kyeong-Soo   (Department of Pharmacy, Chungnam National UniversityUU0001302  );
  • 초록

    This study examined the effect of pine needle distillate (Pinus densiflora Sieb. et Zucc) on the immune system and hematological parameters. C57BL/6 male mice weighing 20 ~21 g were divided into 3 groups and intraperitonially injected with either 200 $\mu$ L of saline (control), 50% diluted (P50) or 100% pine needle distillate (P100) once a day for 24 days. At the end of the experiment, the mice were anesthetized by ether and peripheral blood was collected from the femoral artery and the spleen was excised. Spleen weight decreased significantly (p $^{+}$ /CD8 sup +/ ratio (p $^{+}$ T cells, while decrease the values of the CD4 $^{+}$ T cells. There were no significant differences in WBC, RBC and platelet counts among the three groups, but hemoglobin and hemoglobin-related parameters and platelet volume increased and red blood cell volumes decreased with the administration of the pine needle distillate. These results suggest that the pine needle distillate may have immunosuppressive effects.


  • 주제어

    immunosuppression .   CD4 .   CD8 .   T cell .   complete blood count .   mouse .   pine needle distillate.  

  • 참고문헌 (31)

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