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韓國營養學會誌 = The Korean journal of nutrition. v.36 no.3, 2003년, pp.262 - 269   피인용횟수: 4

십전대보탕 및 자혈양근탕 첨가 식이가 흰쥐의 철분 생체이용률에 미치는 영향
Effect of Dietary Supplementation of Sypjeondaebotang or Jahyulyanggeuntang on Iron Bioavailability in Rats

양미자   (연세대학교 식품영양학과UU0000936  ); 김연정   (연세대학교 식품영양학과UU0000936  ); 박태선   (연세대학교 식품영양학과UU0000936  );
  • 초록

    The effect of dietary supplementation of the two oriental medicinal prescriptions, Sypjeondaebotang or Jahyulyanggeuntang, on iron bioavailability was evaluated in rats which were depleted of iron by being fed an irondeficient diet for 4 weeks. Seventy two iron-depleted rats were randomly divided into 3 groups (n = 24) , and fld one of the following experimental diets for 4 (n = 8), 12 (n = 8), and 25 days (n = 8) : Control diet (CD), Sypjeondaebotang-supplemented diet (SD), Jahyulyanggeuntang -supplemented diet (JD). The CD contained 20 mg Fe/kg diet as FeSO4, and the SD or JD was identical except that the respective oriental medicinal prescription extract was included at the level of 4 g/kg diet. Animals fed the SD and JD for 25 days consumed significantly less food (p<0.001), but showed no change in food efficiency ratio compared to those that were fed the CD. Serum iron concentration and transferrin saturation values were significantly higher in rats fed the SD for 25 days compared to those that were fed the CD for the same period (p 0.05) were lower in rats fed the SD compared to those fed the CD. Dietary supplementation of Sypjeondaebotang during the period of iron repletion significantly increased blood levels of hemoglobin (p


  • 주제어

    Sypjeondaebotang .   Jahyulyanggeuntang .   iron bioavailability .   hemoglobin-repletion bioassay .   chemical balance study.  

  • 참고문헌 (20)

    1. Breymann C. Iron deficiency and anemia in pregnancy: modern aspects of diagnosis and therapy. Blood Cells, Molecules, and Diseases 29(3): 506-516, 2002 
    2. Yu S, West C, Beynen A. Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats. Br J Nutr 71:887-895, 1994 
    3. 구본홍, 정규만. 십전대보탕에 관한 문헌적 고찰, 동서의학 5(2): 16-20, 1980 
    4. Reeves PG, Nielsen FH, Fahey GC. AlN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AlN-76A rodent diet. J Nutr 123: 1939-1951, 1993 
    5. Miller J, McNeal LS. Bioavailability of egg yolk measured by hemoglobin regeneration in anemic rats. J Nutr 113: 115-123, 1983 
    6. Association of Official Analytical Chemists. Official methods of analysis, 16th ed., pp.62-63, AOAC International, Arlington, 1995 
    7. Breymann C. Iron deficiency and anemia in pregnancy: modern aspects of diagnosis and therapy. Blood Cells, Molecules, and Diseases 29(3): 506-516, 2002 
    8. Hwang JB, Yang MO, Shin HK. Survey for approximate composition and mineral content of medicinal herbs. Korean J Food Sci Technol 29(4): 671-679, 1997 
    9. Ahn HS, Lee JY, Kim SK. Assessment of dietary iron availability and analysis of dietary factors affecting hematological indices in iron deficiency anemic female high school students. Korean J Nutrition 32(7): 787-792, 1999 
    10. Sandstrom B, Davidsson L, Cederblad A, Lonnerdal B. Oral iron, dietary ligands and zinc absorption. J Nutr 115: 411-414, 1985 
    11. Tchai BS, Kang EJ, Lee, Han JH. A study on the anemia prevalence in Korea. Korean J Nutrition 14(4): 182-189, 1981 
    12. Lim HJ, Hwang GS, Park T. Effects of the oriental medicinal prescriptions, Jahyulyangeun-tang and Yanghyuljangeunkeonbohwan, on calcium absorption in the human colon carcinoma cell line (Caco-2 cells). Korean J Nutrition 35(4) : 446-453, 2002     
    13. Ravel R. Clinical laboratory medicine: clinical application of laboratory data, 5th ed., Year Book Medical Publishers, Chicago, 1989 
    14. Jo SK, Yu YB, Oh H, Kim SR, Kim SH. The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. J Kor Soc Food Sci Nutr 29(1) : 93-98, 2000 
    15. 윤진숙, 철분영양상태 향상을 위한 방안. 한국영양학회지 33(8):924-927, 2000 
    16. 이기완, 박영심, 박태선, 김은경, 장미라. 한국인의 식생활 100년 평가 (I), 신광출판사, 서울, 1998 
    17. Mei QB, Tao TY, Cui B. Advances in the pharmacological studies of Radix Angelica Sinensis (Oliv) Diels (Chinese Danggui). Chin Med J Engl 104: 776-781, 1991 
    18. Miller J. Factors affecting evaluation of relative biological value of dietary iron for rats. J Nutr 112: 2381-2385, 1982 
    19. Hallberg L, Hulthen L, Garby L. Iron stores in man in relation to diet and iron requirements. Eur J Clin Nutr 52(9):623-631, 1998 
    20. Kye SH, Paik HY. Iron nutriture and related dietary factors in apparently healthy young Korean women (2): analysis of iron in major food items and assessment of intake and availability of dietary iron. Korean J Nutrition 26 (6) : 703-714, 1993 
  • 이 논문을 인용한 문헌 (4)

    1. Woo, Jeong-Hwa ; Choi, In-Young ; Choue, Ryo-Won 2007. "Hematological Effects of Water Extracts of Cham-Dang-Gui on Dietary Induced Iron Deficient Anemia Rat" 韓國營養學會誌 = The Korean journal of nutrition., 40(5): 428~434     
    2. Cho, Hye-Jin ; Lee, Hyun-Sun ; Jung, Eun-Young ; Park, So-Yeon ; Lim, Woo-Taek ; Lee, Jeong-Yong ; Yeon, Seong-Ho ; Lee, Jin-Chae ; Suh, Hyung-Joo 2010. "Manufacturing of Iron Binding Peptide Using Sericin Hydrolysate and Its Bioavailability in Iron Deficient Rat" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(10): 1446~1451     
    3. Yang, Min-Cheol ; Jeong, Sang-Won ; Ma, Jin-Yeul 2011. "Analysis of Constituents in Sipjundaebo-tangs Fermented by Lactic Acid Bacteria" 한국미생물·생명공학회지 = Korean journal of microbiology and biotechnology, 39(4): 350~356     
    4. Jung, Hoon ; Park, So-Jung ; Lee, Hyung-Eun ; Kim, Binnara ; Lee, Eun-Jung ; Oh, Min-Seok ; Heo, Dong Seok 2014. "Review on the Study of Sibjeondaebo-tang (Shiquan dabutang) Published in Korea from 2000 to 2013" Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, 24(1): 47~53   

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