본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

韓國營養學會誌 = The Korean journal of nutrition. v.36 no.3, 2003년, pp.287 - 297   피인용횟수: 2

스피루리나 복용이 노인의 혈중 지질 농도, 항산화능 및 면역능에 미치는 영향
The Effect of Spirulina on Lipid Metabolism, Antioxidant Gapacity and Immune Function in Korean Elderlies

김화영   (이화여자대학교 식품영양학과UU0001056  ); 박지예   (이화여자대학교 식품영양학과UU0001056  );
  • 초록

    This intervention study was performed to assess the effect of spirulina on lipid metabolism, antioxidant capacity, and immune function in elderly Koreans. The subjects were 6 male and 6 female people between the ages of 60 and 75, who were given spirulina supplements of 7.5 g/day for 24 weeks. Dietary intake, anthropometric measurements and biochemical assessment for plasma lipid levels, antioxidant status and immune function were measured before and throughout the intervention period. Before entering the study, the subjects were in relatively good health. Their nutrient intake was satisfactory, and anthropometric indices and plasma nutrient levels were within the normal range. Spirulina supplementation for 24 weeks did not affect dietary intake and anthropometric parameters. However, considerable changes were observed in blood lipid profiles, antioxidant capacity, and immune indices. The plasma concentrations of triglycerides, total- and LDL-cholesterol decreased from 4 weeks of the supplementation period. The antioxidant capacity improved, as shown in increasing TAS and decreasing TBARS after supplementation. Improved immune function was also observed as the PBL lymphocyte proliferation rate and plasma C3 levels increased. The above effects of spirulina supplementation did not differ between mild hypercholesterolemic (cholesterol $\geq$ 200mg/d1) and normochole-sterolemic (cholesterol


  • 주제어

    spirulina .   lipidemia .   antioxidant capacity .   immune function .   intervention study .   elderly.  

  • 참고문헌 (38)

    1. Yagi K. Assay for blood plasma or serum. Methods in Enzymology Academic Press Inc NY 105: 328-331, 1984 
    2. Gonzalez de Rivera C. Miranda-Zamora R. Diaz-Zagoya JC. Juarez-Oropeza MA. Preventive effect of spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report. Life Sci 53(1): 57-61, 1993 
    3. Salazar M. Martinez E. Madrigal E. Ruiz LE. Chamorro GA. Subchronic toxicity study in mice fed Spirulina maxima. J Ethnopharmacology 62(3): 235-241, 1998 
    4. Puyfoulhoux G, Rouanet JM, Besancon P, Baroux B, Baccou JC, Caporiccio B. Iron availability from iron-fortified spirulina by an in vitro digestion/Caco-2 cell culture model. J Agric Food Chem 49(3): 1625-1629, 2001 
    5. Annapurna VV, Deosthale YG, Bamji MS, Spirulina as a source of vitamin A. Plant Food Hum Nutr 41(2): 125-134, 1991 
    6. Jenkins MY, Sheikh NM, Mitchell GV, Grundel E, Blakely SR, Carter CJ. Dietary carotenoids influenced biochemical but not morphological changes in adult male rets fed a choline-deficient diet. Nutr Cancer 19(1): 55-65, 1993 
    7. Qureshi MA, Garich JP, Kidd MT. Dietary Spirulina plantensis enhanres hamoral and cell-mediated immune functions in chickens. Immunopharmacol Immunotoxicol 18(3):405-476, 1996 
    8. The Korean nutrition society. Nutritional assessment program, 'Can-pro 1.0',1997 
    9. The Korean nutrition society. Recommended dietary allowances for Koreans. 7th, 2000 
    10. Korean guidelines of hyperlipidemia treatment for prevention of atherosclerosis. Korean society of lipidology and therosclerosis, 2002 
    11. Rodriguez-Hemandez A, Ble-castillo JL, Juarez-Oropeza MA, Diaz-Zagoya JC. Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with expermental diabetes. Life Sci 20:69(9):1029-1037, 2001 
    12. Iwata K. Inayama T. Kato T. Effects of spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats. J of Nutritional Science & Vitaminology 36(2): 165-171, 1990 
    13. Ahn JH, Kim SS, Kim TH, Lee JH, Ohh SJ, Lee JH, Lee HY. The treatment of swine wastes and simultaneous productions of biomass by the growth of spirulina platensis. Kor J Appl Microbiol Biotechnol 24: 519-524, 1999 
    14. Torres-Duran PV, Miranda-Zamora R, Paredes-Carbajal MC, Masher D, Ble-Castillo J, Diaz-Zagoya JC, Juarez-Oropez MA. Studies on the preventive effect of spilulina maxima on fatty liver development induced by carbon tetracholoride, in the rat. J Ethnopharmacol 64(2): 141-147, 1999 
    15. Upasani CD, Khera A, Balaraman R. Effect of lead with vitamin E, C or spirulina on malondialehyde, conjugated dienes and hydroperoxides in rats. Indian J Exp 39(1):70-74, 2001 
    16. Nakaya N, Homma Y, Goto Y. Cholesterol lowering effect of spirulina. Nutr Rep Int 37: 1329-1337, 1988 
    17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983 
    18. Fiedewald WT, Levy RI, Fredireck DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18:499-502, 1972 
    19. Sin HM. Effects of spirulina and seaweed on growth of lactic acid bacteria. Korea Univ, 1980 
    20. Ministry of health and welfare. Report on 1998 national health and nutrition survey. Seoul, 1999 
    21. Becker EW, Jakober R, Lufr D, Schmulling RM. Clinical and biochemical evaluation of the alga Spirulina with regard to its application in the treatment of obesity. a couble-blind corss-over study. Nutr Rep Int 33: 565-572, 1986 
    22. Hayashi O, Isobe K, Hirahashi T, Katoh T, Okuwaki Y. Bactericidal activity of mouse macrophages stimulated with Spirulina plantensis. J Kagawa Nutr Univ 26: 71-77, 1995 
    23. Liu L, Guo B, Ruan J, Dai X, Chen L, Wu B. Study on effect and mechanism of polysaccharides on spirulina plantensison body immune functions improvement. Marine Sci 6: 44-49, 1991 
    24. Choi JH, Kim MH, Cho MS, Lee HS, Kim WY. The nutritional status and dietary pattern by BMI in Korean elderly. The Korean Nutrition Society 35(4):480-488, 2002     
    25. Mitchell GV, Grundel E, Jenkins MY, Blakely SR. Effects of graded dietary levels of spirulina maxima on vitamin A and E in male rats. J Nutr 120(1O): 1235-1240, 1990 
    26. Korean society of lipidology and therosclerosis , Korean guidelines of hyperlipidemia treatment for prevention of atherosclerosis / v.,pp.,
    27. Effects of spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats , Iwata K;Inayama T;Kato T , J of Nutritional Science & Vitaminology / v.36,pp.165-171,
    28. Dietary Spirulina plantensis enhanres hamoral and cell-mediated immune functions in chickens , Qureshi MA;Garich JP;Kidd MT , Immunopharmacol Immunotoxicol / v.18,pp.405-476,
    29. Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with expermental diabetes , Rodriguez-Hernandez A;Ble-castillo JL;Juarez-Oropeza MA;Diaz-Zagoya JC , Life Sci / v.20;69,pp.1029-1037,
    30. Spirulina as a source of vitamin A , Annapurma VV;Deosthale YG;Bamji MS , Plant Food Hum Nutr / v.41,pp.125-134,
    31. Bactericidal activity of mouse macrophages stimulated with Spirulina plantensis , Hayashi O;Isobe K;Hirahahi T;Katoh T;Okuwaki Y , J Kagawa Nutr Univ / v.26,pp.71-77,
    32. Study on effect and mechanism of polysaxxharides on spirulina plantensison body immune funtions improvement , Liu L;Guo B;Ruan J;Dai X;Chen L;Wu B , Marine Sci / v.6,pp.44-49,
    33. Effect of lead with vitamin E,C or spirulina on malondialehyde,conjugated dienes and hydroperoxides in rats , Upasani CD;Khera A;Balaraman R , Indian J Exp / v.39,pp.70-74,
    34. Studies on the preventive effect of spilulina maxima n fatty liver development induced by carbon tetracholoride,in the rat , Torres-Duran PV;Miranda-Zamora R;Paredes-Carbajal MC;Masher D;Ble-Castillo J;Diaz-Zagoya JC;Juarez-Oropez MA , J Ethnopharmacol / v.64,pp.141-147,
    35. Subchronic toxicity study in mice fed Spirulina maxima , Salazar M;Martinez E;Madrigal E;Ruiz LE;Chamorro GA , J Ethnopharmacology / v.62,pp.235-241,
    36. Dietary carotenoids influenced biochemical but not morphological changes in adult male rets fed a choline-deficient diet , Jenkins MY;Sheikh NM;Mitchell GV;Grundel E;Blakely SR;Carter CJ , Nutr Cancer / v.19,pp.55-65,
    37. Iron availability from iron-fortified spirulina by an in vitro digestion/Caco-2cell culture model , Puyfoulhoux G;Rouanet JM;Besancon P;Baroux B;Baccou JC;Caporiccio B , J Agric Food Chem / v.49,pp.1625-1629,
    38. Effects of graded dietary levels of spirulina maxima on vitamin A and E in male rats , Mitchell GV;Grundel E;Jenkins MY;Blakely SR , J Nutr / v.120,pp.1235-1240,
  • 이 논문을 인용한 문헌 (2)

    1. In, Man-Jin ; Gwon, Su-Yeon ; Chae, Hee-Jeong ; Kim, Dong-Chung ; Kim, Dong-Ho 2007. "Production of Spirulina Extract by Enzymatic Hydrolysis" 한국응용생명화학회지 = Journal of the Korean Society for Applied Biological Chemistry, 50(4): 304~307     
    2. Kim, Hyo-Jin ; Lee, Seung-Hee ; Kim, Mee-Ree 2010. "Quality Characteristics of Spirulina Tofu Prepared with Different Coagulants" 東아시아食生活學會誌 = Journal of the East Asian Society of Dietary Life, 20(5): 769~775     

 저자의 다른 논문

  • 김화영 (55)

    1. 1983 "6세미만 도시 주변거주 어린이의 면역능력에 따르는 영양상태 판정에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 16 (3): 193~199    
    2. 1983 "단백질 급원의 변화와 열량제한 및 식이회복이 흰쥐의 성장발달에 미치는 영향" 韓國營養學會誌 = The Korean journal of nutrition. 16 (4): 263~272    
    3. 1984 "흰쥐에서 대두단백질의 Hypolipidemic 효과에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 17 (1): 68~77    
    4. 1984 "대학생의 영양지식과 식습관에 관한 조사연구" 韓國營養學會誌 = The Korean journal of nutrition. 17 (3): 178~184    
    5. 1985 "체질의학의 체질분류법에 따른 식품기호도와 영양상태의 상관성에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 18 (2): 155~166    
    6. 1991 "음주습관이 중상류층 중년남성의 영양상태에 미치는 영향" 韓國營養學會誌 = The Korean journal of nutrition. 24 (1): 58~65    
    7. 1991 "식이지방수준이 나이에 따른 흰쥐 섬유아세포의 노화과정 및 면역반응에 미치는 영향" 韓國營養學會誌 = The Korean journal of nutrition. 24 (5): 431~441    
    8. 1991 "음주습관이 영양상태에 미치는 영향" 과학과 기술 = The science & technology 24 (6): 82~86    
    9. 1992 "영양상태와 면역능력" 韓國營養學會誌 = The Korean journal of nutrition. 25 (4): 312~320    
    10. 1994 "유방암 및 자궁암의 유발에 영향을 미치는 식이요인에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 27 (10): 1058~1069    
  • 박지예 (0)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 이용한 콘텐츠
이 논문과 함께 출판된 논문 + 더보기