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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology v.8 no.6, 2004년, pp.295 - 300  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex

Kim, Hwang-Soo    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Kim, Hyun-Sok    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Hahn, Sang-June    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Kim, Myung-Jun    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Yoon, Shin Hee    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Jo, Yang-Hyeok    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Kim, Myung-Suk    (Department of Physiology, College of Medicine, The Catholic University of Korea   ); Rhie, Duck-Joo    (Department of Physiology, College of Medicine, The Catholic University of Korea  );
  • 초록

    Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 $(50 {\mu}M)$ , an NMDA receptor antagonist. Whereas bath application of 5-HT $(10 {\mu}M)$ inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine $(PCA,\;10{\mu}M)$ , for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and $10 {\mu}M)$ suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.


  • 주제어

    Serotonin .   Fluoxetine .   Long-term potentiation .   Frontal cortex.  

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