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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology v.8 no.6, 2004년, pp.329 - 333  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Effects of Proinflammatory Cytokines and Natural Products on Mucin Release from Cultured Hamster Tracheal Surface Epithelial Cells

Park, Ji-Sun    (Department of Pharmacology, College of Medicine, Chungnom National University   ); Kim, Hyoung-Soo    (Department of Pharmacology, College of Medicine, Chungnom National University   ); Seok, Jeong-Ho    (Department of Pharmacology, College of Medicine, Chungnom National University   ); Hur, Gang-Min    (Department of Pharmacology, College of Medicine, Chungnom National University   ); Park, Jong-Sun    (Department of Pharmacology, College of Medicine, Chungnom National University   ); Seo, Un-Kyo    (Department of Oriental Medicine, College of Oriental Medicine, Dongguk University   ); Lee, Choong-Jae    (Department of Pharmacology, College of Medicine, Chungnom National University  );
  • 초록

    In this study, we investigated whether TNF-alpha, IL-1beta, CTMA (carboxymethyl trimethylammonium) and LPD (Lup-20[29]-ene-3beta,28-diol) affect mucin release from airway goblet cells and compared the activities of these agents with the inhibitory action of PLL and the stimulatory action of ATP on mucin release. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $^3H-glucosamine$ for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on $^3H-mucin$ release. The results were as follows: TNF-alpha, CTMA and LPD increased mucin release at the highest concentration, but IL-1beta did not. We conclude that CTMA and LPD can stimulate mucin release by directly acting on airway mucin-secreting cells, and suggest that these agents should be further investigated for the possible use as mild expectorants during the treatment of chronic airway diseases.


  • 주제어

    Airway .   Mucin .   Natural products .   TNF-alpha.  

  • 참고문헌 (20)

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