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Natural product sciences v.10 no.6, 2004년, pp.272 - 276  

Antioxidant Activity of (8E,13Z,20Z)-Strobilinin/(7E,13Z,20Z)-Felixinin from a Marine Sponge Psammocinia sp.

Jiang, Ya-Hong    (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University   ); Ryu, Seung-Hee    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); Ahn, Eun-Young    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); You, Song    (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University   ); Lee, Burm-Jong    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); Jung, Jee-H    (College of Pharmacy, Pusan National University   ); Kim, Dong-Kyoo    (Department of Chemistry and Biohealth Products Research Center, Inje University  );
  • 초록

    During the course of our screening for bioactive metabolites from marine sponges, EZZ, the inseparable 1:1 mixture of (8E,13Z,20Z)-strobilinin and (7E,13Z,20Z)-felixinin has been found to deliver significant cytotoxicity against some cancer cell lines. In this study, the antioxidant activity of EZZ was first time evaluated by a series of antioxidant assays. It was found that EZZ was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), but it was comparable to ascorbic acid in scavenging ABTS and superoxide radicals. In addition, EZZ could protect DNA from hydroxyl radical-induced strand cleavage. The findings of the present study suggest that EZZ possess certain antioxidant activity, which might help to prevent occurrence of cancer by alleviating the oxidative stress in cells.


  • 주제어

    furanosesterterpenes .   antioxidant .   radical scavenger.  

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 저자의 다른 논문

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    1. 2004 "Cell Cycle Regulation and Antioxidant Activity of Psammaplin A, A Natural Phenolic Compound from Marine Sponge" Natural product sciences 10 (6): 277~283    
  • 안은영 (1)

  • You, Song (2)

  • 이범종 (29)

  • Jung, Jee-Hyung (21)

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