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Natural product sciences v.10 no.6, 2004년, pp.268 - 271   피인용횟수: 1

P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants in Human Breast Cancer Cells

Kim, Hyang-Rim    (College of Pharmacy, Ewha Womans University   ); Chung, Soo-Yeon    (College of Pharmacy, Ewha Womans University   ); Jeong, Yeon-Hee    (College of Pharmacy, Ewha Womans University   ); Go, Eun-Jung    (College of Pharmacy, Ewha Womans University   ); Han, Ah-Reum    (College of Pharmacy, Ewha Womans University   ); Kim, Na-Hyung    (College of Pharmacy, Ewha Womans University   ); Sung, Min-Kyung    (College of Pharmacy, Ewha Womans University   ); Song, Gi-Na    (College of Pharmacy, Ewha Womans University   ); Jang, Jung-Ok    (College of Pharmacy, Ewha Womans University   ); Nam, Joo-Won    (College of Pharmacy, Ewha Womans University   ); Lee, Hwa-Jeong    (College of Pharmacy, Ewha Womans University   ); Seo, Eun-Kyoung    (College of Pharmacy, Ewha Womans University  );
  • 초록

    In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia mammosa, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to $IC_{50}$ values of less than $6.62\;{\mu}M$ , which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with $IC_{50}$ values between 6.62 and $13.20\;{\mu}M$ . These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.


  • 주제어

    P-glycoprotem .   Indonesian plants .   MCF-7/ADR cell .   daunomycin.  

  • 참고문헌 (11)

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    4. Skehan, P. Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren J. T., Bokesch, H., Kenney, S. and Boyd, M. R. New colorimetric assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990) 
    5. Fardel, O., Lecurer, V. and Guillouzo, A. The P-glycoprotein multidrig transporter. Gen. Phamzac., 27, 1283-1291 (1996) 
    6. Phang, J. M., Poore, C. M., Lopaczynska J. and Yeh, G. C. Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells. Cancer Res., 53, 5977-5981 (1993) 
    7. Go, E. J., Chung, S. Y., Kim, N. H. and Lee, H. J. Modulation of P-glycoprotein activity by flavonoids in human uterine sarcoma cells. J. Kor. Pharm. Sci., 33, 305-310 (2003) 
    8. Christensen, J. G. and LeBlanc, G. A. Reversal of mu1tidrug resistance in vivo by dietary administration of the phytocherrrical indole-3-carbinol. Cancer Res. 56, 574-581 (1996) 
    9. Plouzek, C. A., Ciolino, H. P., Clarke, R. and Yeh, G. C. Inhibirion of P-glycoprotein activiry and reversal of multidrug resistance in vitro by rosemary extract. Eur. J. Cancer, 35, 1541-1545 (1999) 
    10. Scambia, G., Ranelleti, F. O., Panici, P. B., DiVincenzo, R. Bonanno, G., Ferrandina, G., Piantelli, M., Bussa, S., Rumi, C., Cianfriglia, M. and Mancuso, S. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast cancer cell line: P-glycoprotein as a possible target. Cancer Chemother. Pharmacal., 34, 459-464 (1994) 
    11. Chieli, E., Rorrriti, N., Cervelli, F. and Tongiani, R. Effects of flavonols on p-glycoprotein activity in cultured rat hepatocytes. Life Sci., 57, 1741-1751 (1995) 
  • 이 논문을 인용한 문헌 (1)

    1. 2006. "" 藥劑學會誌 = Journal of Korean pharmaceutical sciences, 36(5): 315~320     

 저자의 다른 논문

  • Kim, Hyang-Rim (3)

    1. 2003 "A Potential Cytotoxic Principle of Zingiber cassumunar" Natural product sciences 9 (2): 109~111    
    2. 2004 "Evaluation on the P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants" Natural product sciences 10 (2): 85~88    
    3. 2005 "Cytotoxic Constituents from the Whole Plant of Corydalis pallida" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 28 (11): 1224~1227    
  • Jeong, Yeon-Hee (4)

  • Go, Eun-Jung (8)

  • 한아름 (11)

  • Kim, Na-Hyung (7)

  • Sung, Min-Kyung (4)

  • Jang, Jung-Ok (3)

  • 남주원 (4)

  • Lee , Hwa-Jeong (20)

  • Seo, Eun-Kyoung (23)

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