본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Natural product sciences v.10 no.6, 2004년, pp.277 - 283  

Cell Cycle Regulation and Antioxidant Activity of Psammaplin A, A Natural Phenolic Compound from Marine Sponge

Jiang, Ya-Hong    (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University   ); Ryu, Seung-Hee    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); Ahn, Eun-Young    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); You, Song    (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University   ); Lee, Burm-Jong    (Department of Chemistry and Biohealth Products Research Center, Inje University   ); Jung, Jee-H    (College of Pharmacy, Pusan National University   ); Kim, Dong-Kyoo    (Department of Chemistry and Biohealth Products Research Center, Inje University  );
  • 초록

    Psammaplin A (PSA), a naturally occurring biophenolic compound has been demonstrated to deliver significant cytotoxicity to many cancer cell lines. In this article, we investigated the effect of PSA on cell cycle progression of lung cancer cells (A549). It was found that PSA could slightly perturb the cell cycle progression of A549 cells and lead to the cell cycle arrest at G2/M phase, indicating PSA might disturb the mitosis process of A549 cells. In addition, inspired by the two phenolic groups in the structure of PSA, the antioxidant activity of it has been evaluated. Although PSA was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), it showed stronger ABTS radical scavenging activity than ascorbic acid in TEAC assay. Furthermore, it was found that PSA could effectively prevent DNA strand scission induced by oxidative stress. These results suggest that PSA have both cell cycle regulation and antioxidant activities. Herein, we suggest that PSA would be a very interesting and promising candidate to be developed as a multi-function drug.

  • 주제어

    psammaplin A .   cell cycle arrest .   antioxidant .   radical scavenger.  

  • 참고문헌 (25)

    1. Decker, E.A, The role of phenolics, conjugated linoleic acid, carnosine and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutr: Rev. 53, 49-58 (1995) 
    2. Keum, Y.S., Park, K.K, Lee, lM., Chun, KS., Park, J.H., Lee, S.K, Kwon, H., and Surh, Y.J., Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett. 150, 41-48 (2000) 
    3. Lien, E.J., Ren, S., Bui, H.H., and Wang, R., Quantitative structure-activity relationship analysis of phenolic antioxidants. Free Radic. BioI. Med. 26, 285-294 (1999) 
    4. Nicolaou, K.C., Houghes, R., Pfefferkorn, J.A, Barluenga, S., and Roeker, A,J., Combinatorial synthesis through disulfide exchange: discovery of potent psanunaplin A type antibacterial agents active against Methicillin-Resistant Staphylococcus aureus (MRSA). Chem. Eur. J. 7,4280-4295 (2001b) 
    5. Briviba, K and Sies, H., Nonenzymatic antioxidant defense systems, in Frei, B. (eds.), Natural Antioxidants in Human Health and Disease, Academic Press, New York, 1994, pp. 107-128 
    6. Nicolaou, KC., Houghes, R., Pfefferkorn, J.A, and Barluenga, S., Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphy lococcus aureus (MRSA). Chem. Eur. J. 7, 4296-4310 (2001a) 
    7. Clement, M.V., Hirpara, J.L., Chawdhury, S.H., and Pervaiz, S., Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood. 92, 996-1002 (1998) 
    8. Blois, M.S., Antioxidant determinations by the use of a stable free radical. Nature 181, 1199-1200 (1958) 
    9. Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., and Rice-Evans, C., Antioxidant activity applying an improved ABTS radical cation decolorized assay. Free Radic. Biol. Med. 26, 1231-1237 (1999) 
    10. Jiang, Y.H., Ahn, E.Y, Ryu, S.H., Kim, D.K, Park, J.S., Yoon, H.J., You, S., Lee, B.J., Lee, D.S., and Jung, J.H., Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication. BMC Cancer 4, 70 (2004) 
    11. Arabshahi, L. and Schmitz, F.J., Brominated tyrosine metabolites from an unidentified sponge. J. Org. Chern. 52, 3584-3586 (1987) 
    12. Sanchez-Moreno, C., Larrauri, J.A., and Saura-Calixto, F, Free radical scavenging capacity and inhibition of lipid oxidation of wines, grape juices and related polyphenolic constituents. Food Res. Int. 32, 407-412 (1999) 
    13. Borek, C., Dietary antioxidants and human cancer. Integr Cancer Ther. 3, 333-341 (2004) 
    14. Cerutti, P, Oxy-radicals and cancer. Lancet. 344, 862-863 (1994) 
    15. Adams, J.D. and Odunze, I.N., Oxygen free radicals and Parkinson disease. Free Radie. BioI. Med. 10,161-169 (1991) 
    16. Block, K.I, Antioxidants and cancer therapy: Furthering the debate. Integr Cancer Ther. 3, 342-348 (2004) 
    17. Pina, I.C., Gautschi J.T., Wang, G.Y.S., Sanders, M.L., Schmitz, FJ., France, D., Kennon, S.C., Sarnbucetti, L.C., Remiszewski, S.W., Perez, L.B., Bair, K.W., and Crews, P, Psammaplins from the sponge pseudocerutina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase. J. Org. Chern. 68, 3866-3873 (2003) 
    18. Mitchell, J.H., Gardner, PT., McPhail, D.B., Morrice, PC., Collins, AR., and Duthie, G.G., Antioxidant efficacy of phytoestrogens in chemical and biological model system. Arch. Biochern. Biophys. 360,142-148 (1998) 
    19. Cottelle, N., Bernier, J.L., Catteau, J.P., Pommery, P., Wallet, J.C., and Gadou, E.M., Antioxidant propelties of hydroxyl-flavones. Free Radic. BioI. Med. 20, 35-43 (1996) 
    20. Hideyuki, T., Munetaka, I., Fumio, O., Kazumi, S., Tomoyuki, H., Keiji, S., and Masami W., A water-soluble tetrazolium salt useful for colorimetric cell viability assay. Anal. Cornrnun. 36, 47-50 (1999) 
    21. Russo, A., Acquaviva, R., Campisi, A., Sorrenti, v., Di-Giacomo, C., Vtrgata, G., Barcellona, ML, and Vanella, A., Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. Cell Biol. Toxicol. 16, 91-98 (2000) 
    22. Stoner, G.D. and Mukhtar, H., Polyphenols as cancer chemopre ventive agents. J Cell Biochem Suppl. 22, 169-80 (1995) 
    23. Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, M.B., and Kromhout, D., Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study. Lancet. 342, 1007-1011 (1993) 
    24. Ju, E.M., Lee, S.F., Hwang, H.J., and Kim, J.H., Antioxidant and anticancer activity of extract from Betula platyphylla var. japonica. Life Sci. 74, 1013-1026 (2004) 
    25. Kim, D., Lee, I.S., Jung, J.H., and Yang, S.H., Psammaplin A, a natural bromotyrosine derivative trom a sponge, possesses the antibacterial activity against Methicillin-resistant Staphyloco ccusa ureus and the DNA gyrase-inhibitory activity. Arch. Phann. Res. 22, 25-29 (1999) 

 저자의 다른 논문

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역


  • NDSL :

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기