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Natural product sciences v.10 no.6, 2004년, pp.330 - 334   피인용횟수: 3

Anti-oxidative Phenolic Compounds from Sophorae Fructus

Kim, Hyun-Jung    (College of Pharmacy, Chung Ang University   ); Kim, Min-Kee    (College of Pharmacy, Chung Ang University   ); Shim, Jae-Gul    (College of Pharmacy, Chung Ang University   ); Yeom, Seung-Hwan    (College of Pharmacy, Chung Ang University   ); Kwon, Suk-Hyung    (College of Pharmacy, Chung Ang University   ); Lee, Min-Won    (College of Pharmacy, Chung Ang University  );
  • 초록

    Four isoflavonoids and three flavonoids, and a gallotannin were isolated from the fruits of Sophora japonica (Leguminosae). Their structures were identified as genistein (1), sophoricoside (2), genistein-4'-O--L-rhamnopyranoside (3), $genistein-4'-O-{\alpha}-L-rhamnopyranosly-(1{\rightarrow}2)-{\beta}-D-glucopyranoside$ (4), $kaempferol-3-O-{\alpha}-D-sophoroside$ (5), $kaempferol-3-O-{\beta}-D-glucopyranosyl-(1{\rightarrow}2)-{\alpha}-L-rhamnopyranosly-(1{\rightarrow}6)-{\beta}-D-glucopyranoside$ (6), rutin (7) and gallic acid $4-O-{\beta}-D-(6'-O-galloyl)-glucopyranoside$ (8) by chemical and spectroscopic analysis and comparisons with previously reported spectral data. Compounds 3 and 8 were isolated for the first time from this plant. Anti-oxidative activity was evaluated for the isolated compounds. 8 exhibited potent anti-oxidative activity against the radical scavenging ability of DPPH with the $IC_{50}$ value of $17.1\;{\mu}g/ml$ .


  • 주제어

    Sophorae Fructus .   isoflavonoids .   flavonoids .   gallotannin .   antioxidative activity .   DPPH.  

  • 참고문헌 (17)

    1. Djerrassi, C., Dictionary of Natural Products. Vol 5. Chapman and Hall, pp. 5471 and 5796 (1994) 
    2. Harbome, J.B., and Mabry, T.J., The Flavonoids. Chapman and Hall, pp. 105 (1982) 
    3. Lee, YA., Cho, S.M., and Lee, M.W., Flavonoids from the Roots of Rhodiola sachalinensis. Kor. J. Phannacogn. 33: 116-119 (2002) 
    4. Lewis P.T., and Wahala K., Regiospecific 4-O--glucosidation of isoflavones. Tetrahedron Letters., 39, 9559-9562 (1998) 
    5. Nonaka, G., and Nishioka I., Tannins and Related Compounds. X. Rhubarb (2) : Isolation and structures of a glycerol gallate, gallic acid glucoside gallates, galloylgiucoses and isolindleyin. Chem. Pham. Bull. 31:1652-1658 (1983) 
    6. Jeffrey, B., Harbome, F.R.S., and Herbert, B., The Handbooks of Natural Flavonoids. Vol 2. pp. 671 (1999) 
    7. Harbome, J.B., and Mabry, T.J., The Flavonoids. Chapman and Hall, pp. 105 (1982) 
    8. Wenzel, D., Kuntz, S., Brendel, M.D., and Daniel, H., Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res., 60, 3823-3831 (2000) 
    9. Kim, T.W., The Woody Plants of Korea in Color., Kyo-Hak Publishing Co., Seoul, Korea. pp. 399 (1995) 
    10. Agrawal, P.K., Carbon-13 NMR of flavonoids. Elsevier. pp. 347 (1989) 
    11. Nature, and Medicin study association of Korea, Life-Chinese Medicine' FolkMedicine. DongBu-MunHwaSa. pp. 21 (1985) 
    12. Park, Y.K., Lee, H.J., Choi, D.H., Kwon, Y.H., and Oh, J.S., Extractives from the Bark of Sophora japonica L. Mokchae Konghak. 30: 42-47 (2002) 
    13. Saxena, Y.K., and Madhuri Singai, Genistein 4'-O-$\alpha$-L-rhamno pyranoside from Pithecellobium dulce. Fitoterapia. 69: 305-306 (1998) 
    14. Takeda, T., Ishiguro, I., Masegi, M., and Ogihara, Y., New isoflavone glycosides from the woods of Sophora japonica. Phytochemistry. 16: 619-620 (1997) 
    15. Kim, Y.R., Isolation of rutin from Amaranthus mangotanus. Kor. J. Pharmacogn. 31: 249-251 (2000) 
    16. Shirataki, Y., Takaya, Y., Yokoe, I., and Komatsu, M., Soporaside A, A new aromatic glycoside from the roots of Sophora japonica. Chern, Pharm. Bull. 35: 1637-1640 (1987) 
    17. Michael, E.E., Manual of cultivated broad-leaved trees & shrubs. Volume, Timber Press, Protland, Oregon. pp. 325-327 (1986) 
  • 이 논문을 인용한 문헌 (3)

    1. Hong, Ju-Yeon ; Shin, Seung-Ryeul ; Bae, Man-Jong ; Bae, Jong-Sup ; Lee, In-Chul ; Kwon, O-Jun ; Jung, Ji-Wook ; Kim, Yong-Han ; Kim, Tae-Hoon 2010. "Pancreatic Lipase Inhibitors Isolated from the Leaves of Cultivated Mountain Ginseng (Panax ginseng)" 한국식품저장유통학회지 = Korean journal of food preservation, 17(5): 727~732     
    2. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(4): 523~530     
    3. 2011. "" Oriental pharmacy and experimental medicine, 11(3): 207~213     

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