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Natural product sciences v.10 no.6, 2004년, pp.335 - 340  

Phytochemical Constituents of the Aerial Parts from Aster hispidus

Lee, Sung-Ok    (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University   ); Choi, Sang-Zin    (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University   ); Choi, Sang-Un    (Korea Research Institute of Chemical Technology   ); Ryu, Shi-Yong    (Korea Research Institute of Chemical Technology   ); Lee, Kang-Ro    (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University  );
  • 초록

    The chromatographic separation of the MeOH extract of the aerial parts from Aster hispidus (Compositae) led to the isolation of eight compounds. Their structures were established by spectroscopic methods to be ${\beta}-amyrin$ (1), oleanolic acid (2), (2R)-1, 2-O-(9Z, 12Z, $15Z-dioctadecatrienoyl)-3-O-{\beta}-D-galactopyranosyl\;glycerol$ (3), trans-phytol (4), 9, 12, 15-octadecatrienoic acid (5), kaempferol (6), 3,5-dicaffeoyl quinic acid (7), 3,4-dicaffeoyl quinic acid (8) and kaempferol-3-O-rutinoside (9). Compounds 1, $3{\sim}6$ and 9 showed non-specific moderate cytotoxicity against five human tumor cell lines $(5.44{\sim}23.51\;{\mu}g/ml)$ . The other compounds were of marginal activity against tested five human cancer cell lines $(9.05{\sim}>30.0\;{\mu}g/ml)$ .


  • 주제어

    Aster hispidus .   Compositae .   terpenoid .   flavonoid .   cytotoxicity.  

  • 참고문헌 (15)

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  • 최상운 (69)

  • Ryu, Shi-Yong (69)

  • Lee, Kang-Ro (98)

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