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Natural product sciences v.10 no.6, 2004년, pp.344 - 346   피인용횟수: 3

Nitric oxide and $ProstaglandinE_2$ Synthesis Inhibitory Activities of Flavonoids from the Barks of Ulmus macrocarpa

Kim, Hyun-Jung    (College of Pharmacy, Chung Ang University   ); Yeom, Seung-Hwan    (College of Pharmacy, Chung Ang University   ); Kim, Min-Kee    (College of Pharmacy, Chung Ang University   ); Shim, Jae-Geul    (College of Pharmacy, Chung Ang University   ); Lim, Hyun-Woo    (College of Pharmacy, Chung Ang University   ); Lee, Min-Won    (College of Pharmacy, Chung Ang University  );
  • 초록

    Eight phenolic compounds (1-8) which were isolated from the barks of Ulmus macrocarpa were evaluated for their inhibitory activities on nitric oxide (NO) and prostagrandin $E_2$ (COX-2) production in $interferon-{\gamma}\;(INF-{\gamma})$ and lipopolysaccharide (LPS)-activated RAW 264.7 cells in vitro. NO and COX-2 levels were moderately reduced by the addition of compounds (1-8). Among them 3,4,5,6,7 and 8 inhibited NO production in a dose dependent manner with an $IC_{50}$ of 92.2, 97.3, 36.1, 43.5, 32.8, 39.4 and 37.1 ${\mu}g/ml$ , respectively (positive control, L-NMMA; 36.4 ${\mu}g/ml$ ), and 3,4,5,6,7 and 8 reduced the COX-2 level in a dose dependent manner with an $IC_{50}$ of 43.2, 24.8, 24.8, 33.4, 44.8 and 22.7 ${\mu}g/ml$ , respectively (positive control, indomethacin; 23.4 ${\mu}g/ml$ ). These results suggest that the phenolic compounds may be developed as potential anti-inflammatory and cancer chemopreventive agents.


  • 주제어

    Ulmus marcroparca .   Ulmaceae .   flavanone .   flavan 3-ol .   Nitric oxide .   cyclooxygenase-2 .   anti-inflammation .   cancer chemoprevention.  

  • 참고문헌 (14)

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  • 이 논문을 인용한 문헌 (3)

    1. 2006. "" Natural product sciences, 12(4): 221~225     
    2. 2010. "" Biomolecules & therapeutics, 18(3): 321~328     
    3. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1459~1466     

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